Cruciferous vegetables and Endometrial cancer

 Posted by Chantel Martiromo,  Article By Kyle J. Norton 

Cruciferous vegetables are the group of  vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.
Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.

Nutrients and chemical constituents
1. Carbohydrates
2. Sugars
3. Dietary fiber
4. Omega 3 fatty acid
5. Protein
6. Beta-carotene
7. Lutein and
8. Zeaxanthin
9. Thiamine (Vitamin B1)
10. Riboflavin (Vitamin B2)
11. Niacin (Vitamin B3)
12. Pantothenic acid (B5)
13. Vitamin B6
14. Folate (Vit. B9)
15. Vitamin C
16. Calcium
17. Tryptophan
18. Iron
19. Magnesium
20. Phosphorus
21.Potassium
22. Zinc
23. Etc.
Its chemical constutuents include  glucosinolates, dithiolthiones, indoles , glucoraphanin, s-methyl cysteine sulfoxide, isothiocyanates, indole-3-carbinol, etc..

The effects
The prevalence of endometrial cancer is very common in women in US. some researchers suggested this may the result of widespread of obesity in the female population.  In the evaluation of one cohort study and 16 case-control studies in various aspects of consumption, showed that intake of Cruciferous vegetables is associated to decreased risk of Endometrial cancer. Other in rat study of the effects of Indole-3-carbinol (I3C) found in cruciferous vegetables, found that dietary I3C inhibited spontaneous occurrence of endometrial adenocarcinoma. These results suggested that daily intake of
Cruciferous vegetables are necessary for women in reducing risk of endometrial cancer. Unfortunately, in certain study, dietary Indole-3-carbinol (I3C) is associated in increased risk of endometrial cancer, as induction of Cytochrome P450 enzymes family 1  in the liver and sequential modulation of estrogen metabolism to increased 4HE might promote the effects of dietary I3C on the development of endometrial cancer. 

The Side effects1. People who has over production of IgM immunoglobulins which makes blood thicken should talk to their doctor before taking high amount of broccoli.
2. Allergic reaction??
3. Etc.

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References
(1) Fruits and vegetables and endometrial cancer risk: a systematic literature review and meta-analysis by Bandera EV, Kushi LH, Moore DF, Gifkins DM, McCullough ML.(PubMed)
(2) Chemoprevention of spontaneous endometrial cancer in female Donryu rats by dietary indole-3-carbinol by Kojima T, Tanaka T, Mori H.(PubMed)
(3) Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N'-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolism by Yoshida M, Katashima S, Ando J, Tanaka T, Uematsu F, Nakae D, Maekawa A.(PubMed)