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Friday, January 31, 2014

Cruciferous vegetables and cervical cancer

   Posted by Chantel Martiromo,  Article By Kyle J. Norton  

Cruciferous vegetables are the group of  vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.
Cervical cancer is defined as a condition of the abnormal growth of the cells in the  cervix tissues.

Nutrients and chemical constituents
1. Carbohydrates
2. Sugars
3. Dietary fiber
4. Omega 3 fatty acid
5. Protein
6. Beta-carotene
7. Lutein and
8. Zeaxanthin
9. Thiamine (Vitamin B1)
10. Riboflavin (Vitamin B2)
11. Niacin (Vitamin B3)
12. Pantothenic acid (B5)
13. Vitamin B6
14. Folate (Vit. B9)
15. Vitamin C
16. Calcium
17. Tryptophan
18. Iron
19. Magnesium
20. Phosphorus
21.Potassium
22. Zinc
23. Etc.
Its chemical constutuents include  glucosinolates, dithiolthiones, indoles , glucoraphanin, s-methyl cysteine sulfoxide, isothiocyanates, indole-3-carbinol, etc..


The effects
Evidences of inhibition of tumors and the growth of several types of cultured human cancer cells of Isothiocyanates, a natural phytochamincal found in cruciferous vegetables has been confirmed in animal models. The study of inhibitory effects of BITC and PEITC on metastatic potential of highly metastatic human lung cancer L9981 cells, showed that both benzyl isothiocyanate (BITC) and beta-phenethyl isothiocyanate (PEITC), derived from Isothiocyanates inhibited L9981 cell growth in a dose-dependent manner, by reduced migration and invasion of L9981 cell, regulating metastasis-related gene expression and inhibition of Akt/NFkappaB pathway which plays an important role in regulating viral replication, autoimmune diseases, the inflammatory response, tumorigenesis and apoptosis. Other study suggested that BITC and PEITC also suppressed the metastasis potential of highly metastatic lung cancer cells by inducing apoptosis and cell cycle arrest, via targeting the MAPK/AP-1 pathway.


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The Side effects1. People who has over production of IgM immunoglobulins which makes blood thicken should talk to their doctor before taking high amount of broccoli.
2. Allergic reaction??
3. Etc.


References
(1) Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells by Wu X, Zhu Y, Yan H, Liu B, Li Y, Zhou Q, Xu K.(PubMed)

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