Peony and Non alcoholic liver disease

Mu Dan Pi or Dan Pi (Cortex Moutan Radicis) is also known as peony. The acrid, bitter and mild cool herb has been used in TCM as anti micro organism, anti inflammatory agent and to enhance circulation and immune system, etc., as it clears heat and cools the blood, clears fire of yin deficiency, clear blood stasis and rid of clots, etc., by enhancing the functions of heart, liver and kidney channels.
Non-alcoholic Fatty Liver Disease is defined as a condition of the fatty liver diseases as a result of accumulated of fat in the liver, not caused by abusive alcohol consumption.  

Ingredients 1. Paeonol
2. Paeonoside
3. Paeonolide
4. Apiopaeonoside
5. Ozypaeoniflorin
6. Benzoylpaeoniflorin
7. Benzoyl-oxypaeoniflorin
8. Gallic aid
9. 1,23,4,6-pentagalloylglucose
10. Etc.

The benefits
Peony, a very popular Chinese herb is emerging as in many study for its Anti-inflammatory, anticoagulative , Anti-microbial and cytokine modulating effects, as well as properties as treatments of arthritis and asthma. In the study of the effects of peony in Non alcoholic liver disease caused by insulin resistance with Adult SD rats fed on high-fat-sugar-salt diet for 56 days, then divided randomly into nonalcoholic fatty liver model group, metformin group (0.2 g x kg(-1)) and total glucosides of paeony group. Oral administration of total glucosides of paeony group, hyperinsulinaemia and insulin resistence were resisted, the levels of free fatty acids (FFA), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C)] were decreased, HDL-C were increased, the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholinesterase (ChE) were decreased and superoxide dismutase (SOD) were increased. The contents of malondialdehyde (MDA) were decreased. Of these result, researchers suggested that paeony may consist a potential effect in protecting liver function and modulate serum lipid for the fatty liver rats caused by insulin resistance.

Side Effects 1, Do not use the herb in case of excessive menstruation, bleeding due to Yin deficiency
2. Do not use the herb in newborn, children, or if you are pregnant or breast feeding without first consulting with related field specialist
3. Etc.

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References
(1) Chinese Herbs – Mu Dan Pi or Dan Pi (Cortex Moutan Radicis)
(2) [Effects of total glucosides of paeony on enhancing insulin sensitivity and antagonizing nonalcoholic fatty liver in rats].[Article in Chinese] by Zheng LY, Pan JQ, Lv JH.(PubMed)