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Monday, January 27, 2014

Cruciferous vegetables and Ovarian cancer

Posted by Chantel Martiromo,  Article By Kyle J. Norton 

Cruciferous vegetables are the group of  vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.
Ovarian cancer is defined as a condition of abnormal cells growth of ovarian cells as that have become cancerous. It is one of most common cancer in US, according to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, an estimated 21,880 women in the United States will be diagnosed with ovarian cancer and 13,850 deaths.

Nutrients and chemical constituents
1. Carbohydrates
2. Sugars
3. Dietary fiber
4. Omega 3 fatty acid
5. Protein
6. Beta-carotene
7. Lutein and
8. Zeaxanthin
9. Thiamine (Vitamin B1)
10. Riboflavin (Vitamin B2)
11. Niacin (Vitamin B3)
12. Pantothenic acid (B5)
13. Vitamin B6
14. Folate (Vit. B9)
15. Vitamin C
16. Calcium
17. Tryptophan
18. Iron
19. Magnesium
20. Phosphorus
21.Potassium
22. Zinc
23. Etc.
Its chemical constutuents include  glucosinolates, dithiolthiones, indoles , glucoraphanin, s-methyl cysteine sulfoxide, isothiocyanates, indole-3-carbinol, etc..

The effects
Although conflict results of ingredient of Indole-3-carbinol in Cruciferous vegetables are still in debate, studies of the effects of I3C in therapeutic potential are still ongoing. In the study to compare the effect of I3C bortezomib and cisplatin in several human ovarian cancer cell lines, showed a positive effects, as  co-treatment with I3C and bortezomib significantly inhibited tumour growth and reduced tumour weight compared with either drug alone. Other in the investigation of a a total of 1468 cancers of the oral cavity/pharynx, 505 of the esophagus, 230 of the stomach, 2390 of the colorectum, 185 of the liver, 326 of the pancreas, 852 of the larynx, 3034 of the breast, 367 of the endometrium, 1031 of the ovary, 1294 of the prostate, 767 of the kidney, and 11,492 controls, showed that consumption of cruciferous vegetables at least once a week as compared with no/occasional consumption was significantly reduced for cancer of the oral cavity/pharynx esophagus, colorectum breast, and kidney  but not significant, for stomach, liver, pancreatic, laryngeal, endometrial , ovarian, and prostate cancer.

The Side effects1. People who has over production of IgM immunoglobulins which makes blood thicken should talk to their doctor before taking high amount of broccoli.
2. Allergic reaction??
3. Etc.

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References
(1) Indole-3-carbinol synergistically sensitises ovarian cancer cells to bortezomib treatment.

Taylor-Harding B, Agadjanian H, Nassanian H, Kwon S, Guo X, Miller C, Karlan BY, Orsulic S, Walsh CS.(PubMed)
(2) Cruciferous vegetables and cancer risk in a network of case-control studies by Bosetti C, Filomeno M, Riso P, Polesel J, Levi F, Talamini R, Montella M, Negri E, Franceschi S, La Vecchia C.(PubMed)

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