Posted by Chantel Martiromo, Article By Kyle J. Norton
Cascara sagrada is a species of buckthorn, genus Rhamnus,
belonging to the family Rhamnaceae, native to western North America,
it's bark has been used in traditional medicine for gastrointestinal
support. and it is thought to have a laxative and natural cleansing, etc., effect.
Mastitis is the inflammation of breast tissue, mostly caused by Staphylococcus aureus
the main compound of anthraquinones, otyher compounds include
anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin,
and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides
A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
Nanosilver particles (AAgNPs), a derivative of chemical constituent of
aloin found in Cascara Sagrada may be the protential target used as
antibiotics for treatment of infectious and inflammatory diseases,
including mastitis. In the Staphylococcus aureus induced murine mastitis
study of a total of 40 female mice were divided into five groups of
eight animals each, Nanosilver particles (AAgNPs) is found to be
effective (concentration of 21.8) than antibiotic as it exerted the anti
inflammatory activity in reducing white blood cell (poly-morpho nuclear
cell) infiltration.Other chemical compound emodin found in the herb, in
a study of of the same but with lipopolysaccharide (LPS)-induced mastitis
also found to significantly reduced infiltration of neutrophilic
granulocyte. These result may be given the green light for the chemical
compounds of Cascara Sagrada used as a novel treatment strategy for mastitis.
The Side effects
1. Cascara Sagrada can be liver toxic.
2. It may cause Postal hypertension
Cascara sagrada (CS) has been associated with the development of cholestatic hepatitis, complicated by portal hypertension.
3. Fresh cut, dried bark may cause vomiting and diarrhea.
4. It may allergic effect.
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(1) Emodin ameliorates lipopolysaccharide-induced mastitis
in mice by inhibiting activation of NF-κB and MAPKs signal pathways by
Li D, Zhang N, Cao Y, Zhang W, Su G, Sun Y, Liu Z, Li F, Liang D, Liu B,
Guo M, Fu Y, Zhang X, Yang Z.(PubMed)
(2) Evaluation of therapeutic potential of nanosilver particles
synthesised using aloin in experimental murine mastitis model by
Chaitanya Kumar TV, Muralidhar Y, Prasad PE, Prasad TN, Alpha Raj M.(PubMed)