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Thursday, March 10, 2016

The Best Smoothie of Green Tea, Grape and Flax Seed for Reduced Risk and Treatment of Cystic Fibrosis

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and Treatment of cystic fibrosis
Yield: 2 serving (about 8 ounce each)
13/8 grape
1/8 cup flax seed
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of cystic fibrosis is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Cystic fibrosis is a genetic disease passing through the family affecting the body's epithelial cells. The genetic disease cause the building up of mucus of that may block the lungs and ducts and passageway, causing infection and breathing problem.
Recent discoveries from respectable institutions suggested that green tea(1), grape(4) and flax seed(7) exert theirs antioxidant effects through numerous mechanisms in reduced risk and treatment of cystic fibrosis. Epigallocatechin-3-gallate (EGCg), a green tea component exhibited against Stenotrophomonas maltophilia (Sm) isolates from cystic fibrosis (CF) patients, through significantly reduced Sm bacterial counts in an acute infection model(1) back by its anti microbial activities(2).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years used in traditional Chinese medicine for treatment of various diseases, including cancers and heart diseases.

Dr. Namkung W and the research team at the University of California, in the evaluated CaCC modulators showed that epicatechin, catechin, and malvidin-3-glucoside from green tea inhibited calcium-activated Cl(-) channel (CaCC) for treatment of cystic fibrosis(3).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape wine also exhibited anti Cystic fibrosis effects through ameliorate and modulated CFTR expression and localization for reduced risk of gene mutation causes of development of cystic fibrosis(4).
According to the Liaoning Normal University, two resveratrol oligomers found in from Chinese wild grapevine mimicked the function of transmembrane conductance regulator (CFTR) for treatment of cystic fibrosis(5).
Dr. Yu B and colleagues at the Liaoning Normal University, said, "resveratrol (RES) could potentiate cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel activity(of) two most common forms of CF-related mutation (deltaF508 and G551D-CFTR)"(6).

Omega 3 fatty acids, phytochemincals in the class of Lipids, found abundantly flax seed have shown to associate for reduced risk and treatment of Cystic fibrosis(7).
According to the Harvard Medical School, Massachusetts General Hospital, fatty acid alterations have been found in the blood and tissues of cystic fibrosis (CF) patients(10).
Dr. Oliver anmd Dr., Watson H. in the study of Omega-3 fatty acids for cystic fibrosis,
said, " regular omega-3 supplements may provide some benefits for people with cystic fibrosis with relatively few adverse effects."(8) through restoration of abnormal fatty acid profiles in patients with in cystic fibrosis(9).

The combined epigallocatechin gallate (EGCG), resveratrol and omega 3 fatty acids, found in green tea, grape and flax seed respectively may contribute to further investigation of therapeutic natural ingredients for reduced risk and treatment of cystic fibrosis.
People who are at increased risk of cystic fibrosis.due to family history, genetic mutation,... should drink at least one serving daily and people with cystic fibrosis. should drink as much as they can, depending to digestive toleration.

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(1) Effects of green tea compound epigallocatechin-3-gallate against Stenotrophomonas maltophilia infection and biofilm by Vidigal PG1, Müsken M2, Becker KA3, Häussler S2, Wingender J4, Steinmann E5, Kehrmann J1, Gulbins E3, Buer J1, Rath PM1, Steinmann J1.(PubMed)
(2) Antimicrobial activity of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) against clinical isolates of Stenotrophomonas maltophilia by Gordon NC1, Wareham DW.(PubMed)
(3) Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea by Namkung W1, Thiagarajah JR, Phuan PW, Verkman AS.(PubMed)
(4) Resveratrol rescues cAMP-dependent anionic transport in the cystic fibrosis pancreatic cell line CFPAC1 by Hamdaoui N1, Baudoin-Legros M, Kelly M, Aissat A, Moriceau S, Vieu DL, Colas J, Fritsch J, Edelman A, Planelles G.(PubMed)
(5) Identification of resveratrol oligomers as inhibitors of cystic fibrosis transmembrane conductance regulator by high-throughput screening of natural products from Chinese medicinal plants by Zhang Y1, Yu B1, Sui Y2, Gao X3, Yang H1, Ma T2.(PubMed)
(6) Potentiation of mutant CFTR Cl- channel currents by the naturally occurring stilbene compound resveratrol by Yu B1, Zhang Y1, Sui Y2, Yang S1, Luan J1, Wang X1, Ma T1, Yang H1.(PubMed)
(7) Is there a case for n-3 fatty acid supplementation in cystic fibrosis? by Cawood AL1, Carroll MP, Wootton SA, Calder PC.(PubMed)
(8) Omega-3 fatty acids for cystic fibrosis by Oliver C1, Watson H.(PubMed)
(9) Is there a case for n-3 fatty acid supplementation in cystic fibrosis? by Cawood AL1, Carroll MP, Wootton SA, Calder PC.(PubMed)
(10) Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis by Al-Turkmani MR1, Freedman SD, Laposata M.(PubMed)

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