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Friday, March 11, 2016

Women Health:The Smoothie of Green Tea, Mango and Grape for Reduced Risk and Treatment of HPV (Human Papilloma Virus)

Kyle J. Norton(Scholar, master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for Reduced risk and Treatment of  HPV (Human papilloma virus)
Yield: 2 servings (about 8 ounces each)
1 cup grape
1/2 cup mango or strawberry
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The dream of finding the natural ingredient for prevention and treatment of HPV (Human Papilloma virus)without adverse effects in replacement of conventional medication has not been abated. Some ingredients have to discard because of not achieving the same potent results in human trials.

Scientist community may have found the smoothie(combined ingredients of garlic, olive and coconut oils) with potential and therapeutic value for reduced risk and treatment of  HPV (Human Papilloma virus) without adverse effects.

HPV (human papilloma virus) is a group of sexually transmitted virus which can cause infectious diseases and cancers. According to the disease prevention and control, 50% of sexually active people will have genital HPV at some time in their lives.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the Creighton University, epigallocatechin gallate, theaflavins isolated from green tea may have a potential to prevent sexually transmitted infections caused by HPV (human papilloma virus)(1).

In External genital warts (EGWs), a common sexually transmitted infection caused by HPV, may be treated by green tea polyphenols due to its antioxidant, antiproliferative, antiviral, and antitumor properties(2).

Dr. Rosen T said," mechanisms of action (MOAs).of catechins in the treatment of EGWs and otherHPV-related conditions may be related to or associated with postulated or proven antiviral and immunostimulatory activity"(3).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in grape and blueberry.
According to the joint study lead by the Mahatma Gandhi Institute of Medical Sciences, resveratrol may be a effectively natural compounds against E6 oncoprotein of high risk HPV18(4).

C mimosoides Lamk methanol extracts F21 contained multiple phenolic compounds, such as resveratrol,significantly decreased the viability of all cervical cancer cell lines, including HPV(5).
Furthermore, in HeLa cells (HPV18 positive), as well as in CaSki and SiHa cell lines (HPV16 positive), resveratrol induced cell cycle phase I arrest in cervical cancer cells through apoptosis and autophagy(6).

Gallic acid is a phytochemical in the class of Phenolic acids, found abundantly in tea, mango, strawberries also inhibited HPV through its antioxidant effects. According to the joint study lead by the Xi'an Jiaotong University Health Science Center, gallic acid (GA), attenuated the proliferation of HPVep cells and exhibited significant specificity towards HPV-positive cells via apoptosis and upregulation of antigen p53(7).
In HPV type 16 (CaSki) or 18 (HeLa) cancer cell lines, inhibited CxCa cell proliferation by by inducing apoptosis(8).
Dr. You BR and researchers at the Chonbuk National University,also insisted that Gallic acid (GA) induced cell death through increased reactive oxygen species (ROS) level and GSH (glutathione) depleted cell number in HeLa cells(9).

The Smoothie of Green Tea, Mango and Grape  may hold a key for further studies in production of a curable natural remedy for prevention and treatment of  HPV (Human Papilloma virus).

Women who are at  increased risk of HPV (Human Papilloma virus) due to family history, weaken immunity,....should drink at least one cup or more daily. Women  with HPV (Human Papilloma virus) may drink as much as they can, depending to the digestive toleration.

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(1) Natural polyphenols: potential in the prevention of sexually transmitted viral infections by Date AA1, Destache CJ2(PubMed)
(2) Sinecatechins 10% ointment: a green tea extract for the treatment of external genital warts BY Gupta AK1, Daigle D2.(PubMed)
(3) Green tea catechins: biologic properties, proposed mechanisms of action, and clinical implications. by Rosen T1.(PubMed)
(4) In Silico Docking to Explicate Interface between Plant-Originated Inhibitors and E6 Oncogenic Protein of Highly Threatening Human Papillomavirus 18 by Kumar S1, Jena L1, Sahoo M1, Kakde M1, Daf S2, Varma AK3.(PubMed
(5) Cytotoxic effects of Phytophenolics from Caesalpinia mimosoides Lamk on cervical carcinoma cell lines through an apoptotic pathway by Palasap A1, Limpaiboon T, Boonsiri P, Thapphasaraphong S, Daduang S, Suwannalert P, Daduang J.(PubMed)
(6) Resveratrol induces cell death in cervical cancer cells through apoptosis and autophagy by García-Zepeda SP1, García-Villa E, Díaz-Chávez J, Hernández-Pando R, Gariglio P.(PubMed)
(7) Gallic acid induces apoptosis in human cervical epithelial cells containing human papillomavirus type 16 episomes by Shi L1,2, Lei Y1, Srivastava R2, Qin W3, Chen JJ2,4.(PubMed)
(8) Gallic acid enhancement of gold nanoparticle anticancer activity in cervical cancer cells. by Daduang J1, Palasap A, Daduang S, Boonsiri P, Suwannalert P, Limpaiboon T.(PubMed)
(9) Gallic acid inhibits the growth of HeLa cervical cancer cells via apoptosis and/or necrosis by You BR1, Moon HJ, Han YH, Park WH.(PubMed)

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