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Friday, March 4, 2016

The Effective Smoothie of Green Tea, Peanut and Artichoke for Reduced Risk and Treatment of Leukemia

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published
 on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of  leukemia
Yield: 2 servings (about 8 ounces each)
1 1/4  cups peanut
1/4 cup artichoke
1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

Back by well known institution, according to the recent studies, green tea(1), peanut(4) and artichoke(7) may be next potential therapeutic target for producing a curable medication for reduced risk and treatment of leukemia.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

According to the joint study lead by the The University of Western Australia, the inverse association between green tea consumption and adult leukemia risk probably due to expression of people in the GSTT1-null genotype (OR 0.24; 95 % CI 0.11-0.53) other than GSTT1-normal carriers(2). In chronic myeloid leukemia (CML), green tea polyphenol epigallocatechin-O-gallate exerted the cellular protective effect against progression of cancers through induced apoptosis via the anticholinergic and ASM inhibitor desipramine cGMP/ASM pathway(3).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in  peanuts, also expressed anti leukemia effects through induced apoptosis of human K562 cell line via the regulation of mitochondrial, in converting the energy from food signaling pathways(4).

In human in CCRF-CEM cell lines, resveratrol induced apoptosis in a time and dose- dependent manner through the expression of miR 15a and miR16-1 as tumor suppressors(5).
Dr. Han SY and researchers at the Department of Food Science and Nutrition Hallym University, resveratrol inhibited the cultured rat basophilic leukemia RBL-2H3 cells through suppressed the production of inflammatory Th2 cytokines and  in regulate cell functions of paxillin-linked allergic responses dependent upon MAPK signaling(6).

Silibinin, a major phytochemical found in artichoke displayed anti-cancer activity against various types of cancers and cell lines including Acute Myeloid Leukemia (AML) in dose-depend manner(7), through cytotoxic effects.
In vitro models, K562 and KCL22 cell lines, silibinin also expressed inhibitory effects on cell proliferation, induced apoptosis through reduced mRNA expression levels of some transporter genesincluding the family MRP (8).
In the study of the combinatorial effects of plant polyphenols curcumin, carnosic acid, and silibinin on acute myeloid leukemia cells, Dr. Pesakhov S and colleagues at the Ben-Gurion University of the Negev said, " dietary plant polyphenols--curcumin and carnosic acid--at noncytotoxic concentrations of each agent, produced a synergistic antiproliferative effect and a massive apoptotic cell death in HL-60 and KG-1a human AML cells" and "the potential use of dietary plant polyphenol combinations in the treatment and prevention of AML."(9).

The establishment of combined ingredients of green tea, peanut and artichoke in reduced risk and treatment of leukemia may act as a cornerstone for in deep, large sample size and multi centers study to confirm its effectiveness.

People who are at increased risk of leukemia due to family history, gene mutation, obesity.....should drink at least one serving daily and people with leukemia should drink no more than 4 servings a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

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(1) Lifestyle factors and risk of leukemia and non-Hodgkin's lymphoma: a case-control study by Parodi S1, Santi I2, Marani E3, Casella C3, Puppo A3, Garrone E4, Fontana V5, Stagnaro E6,7.(PubMed)
(2) Green tea consumption and glutathione S-transferases genetic polymorphisms on the risk of adult leukemia by Liu P1, Zhang M2,3, Xie X4, Jin J5, Holman CD2.(PubMed)
(3) Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells by Huang Y1, Kumazoe M1, Bae J1, Yamada S1, Takai M1, Hidaka S1, Yamashita S1, Kim Y1, Won Y1, Murata M1, Tsukamoto S1, Tachibana H1.(PubMed)
(4) Resveratrol induces apoptosis in K562 cells via the regulation of mitochondrial signaling pathways by Wang B1, Liu J1, Gong Z1.(PubMed)
(5) Time--and Concentration--Dependent Effects of Resveratrol on miR 15a and miR16-1 Expression and Apoptosis in the CCRF-CEM Acute Lymphoblastic Leukemia Cell Line by Azimi A1, Hagh MF, Talebi M, Yousefi B, Hossein pour feizi AA, Baradaran B, Movassaghpour AA, Shamsasenjan K, Khanzedeh T, Ghaderi AH, Heydarabad MZ.(PubMed)
(6) Resveratrol Suppresses Cytokine Production Linked to Fc[Formula: see text]RI-MAPK Activation in IgE-Antigen Complex-Exposed Basophilic Mast Cells and Mice by Han SY1, Choi YJ1, Kang MK1, Park JH1, Kang YH1.(PubMed)
(7) Enhancement of the cytotoxic effects of Cytarabine in synergism with Hesperidine and Silibinin in Acute MyeloidLeukemia: An in-vitro approach by Desai UN, Shah KP, Mirza SH, Panchal DK, Parikh SK, Rawal RM1.(PubMed)
(8) The multidrug resistance pumps are inhibited by silibinin and apoptosis induced in K562 and KCL22 leukemiacell lines by Noori-Daloii MR1, Saffari M2, Raoofian R3, Yekaninejad M4, Dinehkabodi OS2, Noori-Daloii AR2.(PubMed)
(9) Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid, and silibinin on proliferation and apoptosis in acute myeloid leukemia cells by Pesakhov S1, Khanin M, Studzinski GP, Danilenko M.(PubMed)

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