Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
The smoothie for reduced risk and Treatment of pulmonary fibrosis
Yield: 2 servings (about 8 ounces each)
1 1/2 cups strawberry
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)
1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately
The finding the natural ingredients for treatment of pulmonary fibrosis is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.
Pulmonary fibrosis is a lung disease caused by damaged and scarred.in lung tissues, leading to serious breathing problems. According to statistic, the most common risk factors of risk factors of pulmonary fibrosis include occupational and environmental exposures, tobacco smoking, gastroesophageal reflux, and genetic factors(1), effecting 200,000 people in the US with 48,000 new cases are diagnosed each year.
According to scientist in some respectable institutions, phytochemicals epigallocatechin-3-gallate
in green tea extract(2) and gallic acid isolated from strawberry may process an effectively potential as therapeutic agents for reduced risk and treatment of pulmonary fibrosis.
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the joint study lead by the Wuhan University, epigallocatechin-3-gallate inhibited pulmonary fibrosis through its antioxidant effects in reduced the expression numerous proinflammatory cytokines(2).
According to Dr. Sriram N and colleagues at the University of Madras, the green tea phytochemical
also protected against the early onset of pulmonary fibrosis through ameliorated bleomycin-induced glycoconjugates, lysosomal hydrolases and ultrastructural changes in the lungs of Wistar rats(3).
Furthermore, Epigallocatechin-3-gallate (EGCG), a polyphenol and a major component of green tea reduced the expression of oxidative stress causes of imbalance between radical-generating and radical scavenging systems in the pathogenesis of pulmonary fibrosis(4).
Gallic acid, a phytochemical in the class of Phenolic acids, found abundantly in strawberries, also exhibited anti pulmonary fibrosis through demonstartion of its antioxidant properties in attenuated oxidative damage and fibrosis induced by Bleomycin (BLM)(5).
According to the Nanhua University study, garlic acid induce apoptosis in tumor cell lines and lung fibroblasts, through anti ROS as a result of c-Jun N-terminal kinases (JNKs) inflammatory signals and cell cycle division of p53 activation, and cell death pathways(6)(7).
Dr. Chuang CY and colleagues at the Chung Shan Medical University said, "Targeting fibroblasts with apoptotic agents represents a major therapeutic intervention for debilitating IPF" and " Gallic acid (3,4,5-trihydroxybenzoic acid), a naturally occurring plant phenol, has been reported to induce apoptosis in tumor cell lines and renal fibroblasts"(8).
The combined epigallocatechin gallate (EGCG) and gallic acid, found in green tea, and strawberry may contribute to further investigation of therapeutic natural ingredients for reduced risk and treatment of Pulmonary fibrosis.
People who are at increased risk of Pulmonary fibrosis due to family history, genetic mutation,... should drink at least one serving daily and people with Pulmonary fibrosis. should drink as much as they can, depending to digestive toleration.
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(1) Epidemiology of idiopathic pulmonary fibrosi by Brett Ley and Harold R Collard(PubMed)
(2) The green tea extract epigallocatechin-3-gallate inhibits irradiation-induced pulmonary fibrosis in adult rats by You H1, Wei L2, Sun WL1, Wang L3, Yang ZL4, Liu Y4, Zheng K5, Wang Y6, Zhang WJ1.(PubMed)
(3) Epigallocatechin-3-gallate exhibits anti-fibrotic effect by attenuating bleomycin-induced glycoconjugates, lysosomal hydrolases and ultrastructural changes in rat model pulmonary fibrosis by Sriram N1, Kalayarasan S, Sudhandiran G.(PubMed)
(4) Enhancement of antioxidant defense system by epigallocatechin-3-gallate during bleomycin induced experimental pulmonary fibrosis by Sriram N1, Kalayarasan S, Sudhandiran G.(PubMed)
(5) Protective effect of gallic acid against bleomycin-induced pulmonary fibrosis in rats by Nikbakht J1, Hemmati AA1, Arzi A1, Mansouri MT2, Rezaie A3, Ghafourian M4.(PubMed)
(6) Gallic Acid Induces a Reactive Oxygen Species-Provoked c-Jun NH2-Terminal Kinase-Dependent Apoptosis in Lung Fibroblasts by Chen CY1, Chen KC, Yang TY, Liu HC, Hsu SL.(PubMed)
(7) Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway. by Chuang CY1, Liu HC, Wu LC, Chen CY, Chang JT, Hsu SL.(PubMed)
(8) Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway by Chuang CY1, Liu HC, Wu LC, Chen CY, Chang JT, Hsu SL.(PubMed)