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Monday, March 21, 2016

The Smoothie of Sweet Potato, Flax seed and Grape for Prevention and Treatment of Nephrogenic Hypertension

    Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
    Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
    Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
    Nominated for shorty award over last 4 years
    Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

    The smoothie for prevention and treatment of Nephrogenic Hypertension 
    Yield: 2 servings (about 8 ounces each)
    1 1/4 cup sweet potato
    1/4  cup fax seed
    1 cup grape

    1. Place all ingredients in a blender and puree about 1 minute
    2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
    3. Serve immediately

    The finding of a natural source for treatment of Nephrogenic Hypertension (Goldblatt kidney) has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.
Nephrogenic Hypertension (Goldblatt kidney) is a medical condition of damage kidney causing decreased blood flow, and thus oxygen supply, to the kidneys (ischemia) in triggering hypertension.

Alpha-tocopheryl acetate (vitamin E acetate) induced a positive effect on the renal function in patient, through reduction of highly-toxic products of lipid peroxidation, improvement of renal microcirculation, reduction of ischemic disorders in the organs of the body(1).
According to an Russian study, highly-toxic products of lipid peroxidation in patients with nephrogenic hypertension may be an indication of chronic kidney failure(2).
3‑n‑butylphthalide (NBP), a natural product of celery seeds exhibited anti Nephrogenic Hypertension effect by alleviated tubular impairment and significantly decreased oxidative stress, as well as the expression of pro‑inflammatory cytokines and TGF-‑β1 in kidney tissues(3).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in skins and seed of grape wine, nuts, peanuts, etc.may also benefit patient with renal hypertension, involving antioxidant actions and nitric oxide generation(4).
Dr. Javkhedkar AA and Dr. Banday AA said, "resveratrol restores renal sodium transport regulation in spontaneously hypertensive rats (SHR)"...." (thr, Drough)activates phase II antioxidant enzymes, mitigates oxidative stress,...."(5).
In the investigation of the effectiveness of Flax lignan cardioprotective, antihyperlipidemic effect Dr.Sawant SH1 and Dr. Bodhankar SL.suggested "flax lignan concentrate (FLC) possessed antihypertensive effect via modulation of endogenous enzymes in deoxycorticosterone acetate (DOCA)-salt induced renal hypertension in rats"(6).

The effectiveness of Sweet Potato, Flax seed and Grape may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Nephrogenic Hypertension (Goldblatt kidney) with little or no adverse effects.

People who are at high risk of Nephrogenic Hypertension (Goldblatt kidney) due to aging, weaken reno function... should drink at least one serving daily and women with Nephrogenic Hypertension (Goldblatt kidney) should drink no more than 4 servings daily, depending to digestive toleration.
Life style and diet pattern change are necessary.

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(1) [The processes of lipid peroxidation and renal functions in nephrogenic hypertension].[Article in Russian] by Bagirova RD, Alekperova NV, Siniachenko OV, Sardarly FZ, Suleĭmanova SG(PubMed)
(2) [The lipid peroxidation process in patients with nephrogenic hypertension and clinico-laboratory signs of chronic kidney failure].[Article in Russian] by Guseĭnov FG, Bagirova RD, Alekperova NV, Vezirov AV, Suleĭmanova SG, Shakhverdieva VG.(PubMed)
(3) Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats by Zhu J1, Zhang Y1, Yang C1.(PubMed)
(4) Resveratrol improves vasoprotective effects of captopril on aortic remodeling and fibrosis triggered by renovascular hypertension by Natalin HM1, Garcia AF1, Ramalho LN2, Restini CB3.(PubMed)
(5) Antioxidant resveratrol restores renal sodium transport regulation in SHR by Javkhedkar AA1, Banday AA2.(PubMed)

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