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Monday, March 28, 2016

The Smoothie of Green tea, Orange and Grape for Prevention and Treatment of Renal Amyloidosis

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Renal Amyloidosis  
Yield: 2 servings (about 8 ounces each)

1/2 cup orange
1 cup grape
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Renal Amyloidosis  has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Green tea, Orange and Grape may be the next generation of natural ingredients for prevention and treatment of Reno Amyloidosis. 

 Renal Amyloidosis is a condition of kidney damage caused by deposited of amyloid, affecting kidney function in filtering wastes and breaking down proteins. According to the joint study led by the Tokushima University Graduate School, (-)-epigallocatechin-3-gallate (EGCG), a tea-derived flavanol, expressed anti Reno Amyloidosis effects by inhibited fibril formation and disaggregated fibrils preformed(1).
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world. An observational study, suggested, green tea consumption is associated to amyloid fibril reduction, due to its (-)-epigallocatechin-3-gallate (EGCG) in significant decrease of left ventricular (LV) myocardial mass through stabilization of wild-type transthyretin amyloid cardiomyopathy (wtATTR-CM)(2).
Furthermore, the phytochemical isolated from green tea also inhibited the progression of Reno Amyloidosis by modulating the rate of formation and structural properties of apolipoprotein C-II amyloid fibrils, the The University of Melbourne, Parkville insisted(3).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in grape and blueberry also inhibited the process of amyloid formation by the normally soluble hormone islet amyloid polypeptide (IAPP) which contributed to β-cell death in type 2 diabetes, according to the Stony Brook University(4).

Vitamin C, one of the powerful may benefit patients with amyloidosis, through its free radical scavenger activity(5). 
According to Dr. Ravid M and colleagues, in animal model, ascorbic acid partially restored the amyloid-degrading activity in dose-dependent manner(6).

The effectiveness of  Green tea, Orange and Grape may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Renal Amyloidosis with little or no adverse effects.

People who are at high risk of Renal Amyloidosis due to aging, weaken reno function... should drink at least one serving daily and women with Renal Amyloidosis  should drink no more than 4 servings daily, depending to digestive toleration.

Life style and diet pattern change are necessary.

(1) The polyphenol (-)-epigallocatechin-3-gallate prevents apoA-IIowa amyloidosis in vitro and protects human embryonic kidney 293 cells against amyloid cytotoxicity by Nakajima H1,2, Nishitsuji K1, Kawashima H3, Kuwabara K1,2, Mikawa S2, Uchimura K4, Akaji K3, Kashiwada Y5, Kobayashi N6, Saito H2,Sakashita N1.(PubMed)
(2) Green tea extract as a treatment for patients with wild-type transthyretin amyloidosis: an observational study by Siepen FA1, Bauer R1, Aurich M1, Buss SJ1, Steen H1, Altland K2, Katus HA1, Kristen AV1(PubMed)
(3) Fluphenazine·HCl and Epigallocatechin Gallate Modulate the Rate of Formation and Structural Properties of Apolipoprotein C-II Amyloid Fibrils by Zlatic CO1, Mao Y1, Ryan TM1, Mok YF1, Roberts BR1, Howlett GJ1, Griffin MD1.(PubMed)
(4) Mutational analysis of the ability of resveratrol to inhibit amyloid formation by islet amyloid polypeptide: critical evaluation of the importance of aromatic-inhibitor and histidine-inhibitor interactions by Tu LH1, Young LM, Wong AG, Ashcroft AE, Radford SE, Raleigh DP.(PubMed)
(6) Ascorbic acid-induced regression of amyloidosis in experimental animals by Ravid M, Chen B, Bernheim J, Kedar I.(PubMed)

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