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Saturday, March 26, 2016

The Fabulous Smoothie of Green Tea, Blueberry and Mango for Prevention and Treatment of Stomach Cancer/Gastric Cancer

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of  Stomach Cancer/Gastric Cancer
Yield: 2 serving (about 8 ounce each)
1 cup blueberry
1/2 cup mango
1 cup green tea drink (Make from 4 grams of green tea and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of  Stomach Cancer/Gastric Cancer has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Stomach cancer is defined as condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

Recent studies back by renowned institutions, conveyed that green tea(1), blueberry(4) and mango(7) may be holding a key for extracting natural ingredient for reduced early onset and treatment of Stomach Cancer/Gastric Cancer. According to the Sichuan University, regular green tea consumption is associated to a minor inverse association of risk of gastric cancer in all population-based case-control studies(1).
Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects,
green tea now has been cultivated all over the world in suitable climate.
The University of Utah School of Medicine study propose the prevention effects of green tea against the early onset of cancers overall(2).
In fact, the conflict results between green tea intake and gastric cancer risk may be due to how the drink was served in temperature wise. One study had shown a significantly lowered GC risk when tea was served warm to cold. Another study also showed a significantly risk with lukewarm tea(3).

Resveratrol, a phytochemical in the class of Stilbenoids, found abundantly in blueberry and grape is also associated to reduce risk of gastric cancer, according to the Cook County Hospital(4).
Dr. Riles WL and colleagues in the investigation of the resveratrol effect against gastric cancer, indicated that the antioxidant up regulating cancer suppressive gene p53 in in SNU-1 and AGS cancer cell lines in different mechanisms(5).
Other study suggested the effectiveness of resveratrol for treatment of gastric cancer probable through intracellular signaling in growth arrest and apoptosis against tumor progression(6).

Gallic acid is a phytochemical in the class of Phenolic acids, found abundantly in mango and strawberries also inhibited gastric cancer cell lines through inhibition of NF-κB, the pro inflammatory cytokines activity(7), in immunoreactivity assay of cytoskeletal F-actin(8).
Dr. Yoshioka K and researchers at the Mie University, suggested, in human stomach cancer KATO III cells, gallic acid exhibited anti the KATO III cell line through induction of apoptosis in concentration- and time-dependen(9).

The finding of the effectiveness of Green Tea, Blueberry and Mango may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of  Stomach Cancer/Gastric Cancer 

People who are at increased risk of Stomach Cancer/Gastric Cancer , due to family history, auto immunity,....should drink the juices at least one a day. People with Stomach Cancer/Gastric Cancer   should drink the juice as much as  as they can depending to digestive toleration.
Life style and diet pattern change are recommended.

(1) Green tea and gastric cancer risk: meta-analysis of epidemiologic studies by Zhou Y1, Li N, Zhuang W, Liu G, Wu T, Yao X, Du L, Wei M, Wu X(PubMed)
(2) Coffee, tea, caffeine intake, and the risk of cancer in the PLCO cohort by Hashibe M1,2, Galeone C3, Buys SS4, Gren L1, Boffetta P5, Zhang ZF6, La Vecchia C7.(PubMed)
(3) Green tea and the risk of gastric cancer: epidemiological evidence by Hou IC, Amarnani S, Chong MT, Bishayee A.(PubMed)
(4) Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce apoptosis in gastric cancer cells by Atten MJ1, Godoy-Romero E, Attar BM, Milson T, Zopel M, Holian O.(PubMed)
(5) Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells by Riles WL1, Erickson J, Nayyar S, Atten MJ, Attar BM, Holian O.(PubMed)
(6) Resveratrol: A potential challenger against gastric cancer by Zulueta A1, Caretti A1, Signorelli P1, Ghidoni R1.(PubMed)
(7) Gallic acid inhibits gastric cancer cells metastasis and invasive growth via increased expression of RhoB, downregulation of AKT/small GTPase signals and inhibition of NF-κB activity by Ho HH1, Chang CS, Ho WC, Liao SY, Lin WL, Wang CJ.(PubMed)
(8) Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-kappaB activity and downregulation of PI3K/AKT/small GTPase signals by Ho HH1, Chang CS, Ho WC, Liao SY, Wu CH, Wang CJ.(PubMed)
(9) Induction of apoptosis by gallic acid in human stomach cancer KATO III and colon adenocarcinoma COLO 205 cell lines by Yoshioka K1, Kataoka T, Hayashi T, Hasegawa M, Ishi Y, Hibasami H.(PubMed)

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