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Tuesday, March 22, 2016

The Delicious Smoothie of Sweet Potato, Orange Juice and Papaya for Prevention and Treatment of Variegate Porphyria

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Variegate Porphyria 
Yield: 2 servings (about 8 ounces each)
1 cup papaya
1/2 cup sweet potato
1 cup of orange juice


1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately


The finding of a natural source for treatment of Variegate Porphyria  has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Sweet Potato, Orange and Papaya may be the next generation of natural ingredients for prevention and treatment of Variegate Porphyria.

Variegate Porphyria is a genetic mutation of enzyme protoporphyrinogen oxidase (PPOX) disease induced disorder of porphyrin-heme metabolism. According to the Universitat de les Illes Balear, patients with Variegate Porphyria are associated to higher antioxidant defenses, greater oxidative stress(1).
Dietary rich of vitamins E(Sweet Potato) and C (Orange)may restore protoporphyrinogen oxidase (PPOX) expression(2) in VP patients and enhances antioxidant glutathione reductase (GRd) and superoxide dismutase (SOD) activities activity(2)(3).
According to Universitat de les Illes Balears, dietary supplementation with vitamin E (50 mg/d) and vitamin C (150 mg/d) for 6 months decreased plasma oxidative damage and enhanced the erythrocyte activities of CAT and GR(3).

Vitamin B6 or pyridoxine found abundantly in papaya, is water soluble and a member of vitamin B complex, played an important role in amino acids metabolism for to maintaining the proper function in our body. According to the University Hospital of L. Pasteur, treatment of pyridoxine (40-60 mg/day) showed significant improvement and had regular ambulatory check-up every three months in patients with variegate porphyria(4).

The effectiveness of Sweet Potato, Orange Juice and Papaya may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Variegate Porphyria with little or no adverse effects.

People who are at high risk of Variegate Porphyria due to aging, weaken immunity, .... should drink at least one serving daily and people with Variegate Porphyria should drink the smoothie as much as they can, depending to digestive toleration.

Life style and dietary pattern change are recommended.


References
(1) Enzyme antioxidant defences and oxidative damage in red blood cells of variegate porphyria patients by Ferrer MD1, Tauler P, Sureda A, Romaguera D, Llompart I, Palacin C, Orfila J, Tur JA, Pons A.(PubMed)
(2) Antioxidants restore protoporphyrinogen oxidase in variegate porphyria patients by Ferrer MD1, Tauler P, Sureda A, Palacín C, Tur JA, Pons A.(PubMed)
(3) Variegate porphyria induces plasma and neutrophil oxidative stress: effects of dietary supplementation with vitamins E and C by Ferrer MD1, Tauler P, Sureda A, Palacín C, Tur JA, Pons A.(PubMed)
(4) Kidney damage in acute intermittent porphyria by Mydlík M1, Derzsiová K.(PubMed)

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