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Monday, August 25, 2014

Ginseng Asia and Polycystic Ovarian Syndrome

Posted by Chantel Martiromo

Epidemically, increased incidence and prevalence of overweight and obesity over 3 decades in the develop world now has spread to South East Asian population, due to over 20 years of economic prosperity causes of lifestyle changes in populations with very different initial habits. Suggestions of reduced fat intake less than 30% of total calories with a low proportion of saturated fat with high in fiber from predominantly low-glycaemic-index-carbohydrate foods is recommended. Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(1)(2).

Polycystic Ovarian Syndrome is defined as endocrinologic diseases caused by undeveloped follicles clumping on the ovaries interfered with the function of the normal ovaries, resulting in enlarged ovaries, hormone imbalance( excessive androgen), male pattern hair development, acne, irregular period or absence of period, weight gain and infertility. The syndrome effects over 5% of women population.

Ginseng Asia is also known as Panax ginseng. Since it has been grown in the cold places in the Asian, Asian ginseng is considered as yang promoting, according to traditional Chinese medicine.
Korean red ginseng extract (KRGE) in the experiment in PCOs induced rat, using the long-acting compound estradiol valerate (EV), regulated sympathetic nerve activity by significantly lower expression of NGF protein (involved in the growth of peripheral nerve cells) and NGF mRNA(the form of RNA that carries information from DNA) involved in the abnormal process caused by steroid-induced PCO(4). Also, in the experiment of Ginseng total saponins (GTS) involved polycystic ovaries induced by a single intramuscular injection of 4 mg estradiol valerate (EV) in rats, GTS decreased the expression of NGF in ovary tissue(5).


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References
(1) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(2) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)
(4) Effect of Korean red ginseng extract in a steroid-induced polycystic ovary murine model by Pak SC, Kim SE, Oh DM, Shim KM, Jeong MJ, Lim SC, Nah SY, Park SH, Kang SS, Moon CJ, Kim JC, Kim SH, Bae CS.(PubMed)
(5) [Effects of ginseng total saponins on nerve growth factor expression in rat with estradiol valerate-induced polycystic ovaries].[Article in Chinese] by Kuang HY, Shao H, Hou LH, Wu XK.(PubMed)

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