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Wednesday, August 27, 2014

Salvia miltiorrhiza (Dan Shen) and PCOs

Posted by Chantel Martiromo

Epidemically, increased incidence and prevalence of overweight and obesity over 3 decades in the develop world now has spread to South East Asian population, due to over 20 years of economic prosperity causes of lifestyle changes in populations with very different initial habits. Suggestions of reduced fat intake less than 30% of total calories with a low proportion of saturated fat with high in fiber from predominantly low-glycaemic-index-carbohydrate foods is recommended. Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(1)(2).

Polycystic Ovarian Syndrome is defined as endocrinologic diseases caused by undeveloped follicles clumping on the ovaries interfered with the function of the normal ovaries, resulting in enlarged ovaries, hormone imbalance( excessive androgen), male pattern hair development, acne, irregular period or absence of period, weight gain and infertility. The syndrome effects over 5% of women population.Dan Shen is also known as Red Sage Root. The bitter and slightly cold herb has been used in TCM as antithrombotic, antihypertonic (lowering blood pressure), antimicrobial, antipyretic, anti-inflammatory, sedative agent and to treat dysmenorrhea, amenorrhea, palpable tumors, angina,restlessness, insomnia, irritability, etc., by enhancing the functions of heart and liver.
Cryptotanshinone, isolated from Salvia miltiorrhiza, in the experiment involved prenatally androgenized (PNA) rats as a model of polycystic ovary syndrome, improved estrous cycles, reduced 17-hydroxyprogesterone, androstenedione, testosterone, glucose, insulin levels, and lowered AUC-Glu(Measurements were made of the area under the curve of glucose by intravenous glucose tolerance test) and HOMA-IR( a method used to quantify insulin resistance and beta-cell function)(8).

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References
(1) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(2) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed)(8) Cryptotanshinone reverses reproductive and metabolic disturbances in prenatally androgenized rats via regulation of ovarian signaling mechanisms and androgen synthesis by Xinming Yang , Yuehui Zhang , Xiaoke Wu , Chun Sik Bae, Lihui Hou , Haixue Kuang , Yongyan Wang , Elisabet Stener-Victorin(American society physiology)

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