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Sunday, October 16, 2011

Soy and acute lymphoblastic leukemia, lymphoma and multiple myeloma cells

Posted by Chantel M. Contributed by US national library of medicine, National Insitute of health

In a study of "Genistein inhibited proliferation and induced apoptosis in acute lymphoblastic leukemia, lymphoma and multiple myeloma cells in vitro" by Li W, Frame LT, Hoo KA, Li Y, D'Cunha N, Cobos E., posted in US National Library of Medicine National Institutes of Health, researchers found that The cell line sensitivity to genistein treatment based on the 50% inhibitory concentration (IC(50)) values in decreasing order of toxicity was found to be as follows: RS4;11 (4.89 ? 4.28 ?M) > GA10 (13.08 ? 3.49 ?M) > Toledo (16.94 ? 3.89 ?M) > CEM (17.31 ? 0.72 ?M) > OPM-2 (46.76 ? 2.26 ?M) > U266 (128.82 ? 1.90 ?M). The mechanism of growth inhibition was through induction of apoptosis and cell cycle arrest. The concomitant altered expression of apoptosis pathway proteins and cell cycle modulators (caspases 9, 3, 7, PARP [poly(ADP-ribose) polymerase], cIAP1 [inhibitor of apoptosis protein 1], Bcl-2 and cyclin B1) were observed by Western blot and real-time polymerase chain reaction (PCR) analyses. In addition, some malignancy-related embryologic pathway proteins, e.g. Notch1 and Gli1, were modulated by genistein treatment in sensitive cell lines.

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