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Friday, October 28, 2011

Soy and MicroRNAs (miRNAs) in Prostate Cancer

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In the study of "miRNAs Differentially Expressed in Prostate Cancer Cell Lines after Soy Treatment" by Rabiau N, Trraf HK, Adjakly M, Bosviel R, Guy L, Fontana L, Bignon YJ, Bernard-Gallon DJ., posted in US National Library of Medicine National Institutes of Health, researchers found that out of 377 miRNAs tested, 180, 170 and 150 miRNAs were amplified with 2% of variation in the triplicate in PC-3, DU145 and LNCap cells, respectively, and only 5 miRNAs for PC-3 and DU145 cells and 4 miRNAs for LNCap exhibited a significant change in their expression. Treatment with genistein or daidzein had similar effects on miRNA regulation to those of 5-AZA treatment and concluded that this work demonstrated a new role of isoflavones on the regulation of miRNAs in prostate cancer.

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