Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health
According to the study of "Genistein, an epigenome modifier during cancer prevention" by Zhang Y, Chen H., posted in US National Library of Medicine National Institutes of Health, researchers found that Genistein, one of the soy-derived bioactive isoflavones, affects tumorigenesis through epigenetic regulations. By modulating chromatin configuration and DNA methylation, genistein activates tumor suppressor genes and affects cancer cell survival. Here, we summarize and discuss both in vitro and in vivo studies in the field that investigate the effect of genistein on histone modifications and DNA methylation. The promising role of genistein in cancer prevention and therapeutic applications will be discussed from an epigenetic point of view.