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Monday, October 17, 2011

Soy isoflavones and cancer cells radiotherapy

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

In The study of "Soy isoflavones sensitize cancer cells to radiotherapy" by Hillman GG, Singh-Gupta V., posted in US National Library of Medicine National Institutes of Health, researchers found that Soy isoflavones could be an effective complementary treatment given that they inhibit the survival signaling pathways of various cancer cells through altered activation of APE1/Ref-1, NF-κB, and HIF-1α, which are genes essential for tumor cell survival, tumor growth, and angiogenesis, thus making such cells more sensitive to radiotherapy. Studies in which soy isoflavones were given in conjunction with radiotherapy to prostate cancer patients suggest that soy isoflavones might also mitigate the adverse effects of radiation on normal tissues, probably by acting as antioxidants. These observations open new avenues for exploiting soy isoflavones as supplements to conventional therapies.

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