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Wednesday, October 12, 2011

Soy and Gene expression

Posted by Chantel M. Contributed by US National Library of Medicine National Institutes of Health

According to the study of "Soy food supplementation, dietary fat reduction and peripheral blood gene expression in postmenopausal women - A randomized, controlled trial" by Wang J, Siegmund K, Tseng CC, Lee AS, Wu AH., posted in US National Library of Medicine National Institutes of Health, researchers found that there were notable changes in gene expression associated with the intervention in the VLFD and SFD groups. Our findings suggest that the expression of nicotinamide phosphoribosyltransferase (NAMPT) and genes related to Fc γ R-mediated phagocytosis and cytokine interactions may be significantly altered in association with dietary fat reduction and soy supplementation. Gene expression changes in NAMPT were somewhat dampened with adjustment for weight but changes related to Fc γ R-mediated phagocytosis and cytokine interactions remained largely unchanged. Conclusion: PBMCs can reveal novel gene expression changes in association with controlled dietary intervention.

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