Chinese Celery, the Prominent Post Stroke Treatment Functional Food

Scientists may have found a whole food for the treatment and improvement of the quality of life of post-stroke patients and without inducing any side effects, according to studies.

Stroke is a medical condition caused by reduced blood flow to the brain, leading to the death of brain cells due to lack of oxygen or bleeding.

In other words, a stroke can either be results of a blocked artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).

A mini-stroke is a temporary disruption of blood flow to the brain that only causes some disruption to the brain by inducing permanent damage.

Depending on the parts of the neuron being damage, patients may experience different symptoms. However, most common symptoms of stroke include paralysis or numbness of the face, arm or leg, problems in vision, speaking, walking and persistent headache.

Certain medical conditions such as diabetes. heart diseases, long-term use of tobacco, the increase in age, ethnicity are some prevalent risk factors of stroke.

Out of many risk factors, people who have hypertension, particularly untreated hypertension and follow the Western diet are at increased risk of the onset of stroke, according to epidemiological studies.

In examining the post-stroke patients, a poor diet pattern with a high in saturated and trans fat, red meat and processed foods have been found in the high percentage, compared to the traditional diet.

Dr. Mehdi Foroughi, the lead scientist in the study of poor diet in the risk of stoke wrote, " adherence to the improvements in nutrition and diet can reduce the incidence of stroke. Higher antioxidant, vitamins, potassium, calcium, vegetables, fruits, whole grain intake, and adherence to the Mediterranean diet or DASH diet can lower stroke incidence".


The statement clearly suggested that a healthy diet rich in fruits and vegetables and whole grain and low in red meat, saturated fat and trans fat, and processed food is the best for prevention and stroke.

Celery is a species of Apium graveolens, belonging to the family Apiaceae. The plant is cultivated all around the globe as a vegetable.

Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

On finding a natural ingredient with no side effect for the treatment of patients with acute ischemic stroke, researchers evaluated the Dl-3-n-butylphthalide (NBP), first isolated from the seeds of celery, efficacy in animal models of stroke.

The randomized, double-blind, double-dummy trial included 573 patients within 48 hours of the onset of ischemic stroke in China.

Patients were randomly assigned to receive a 14-day infusion of NBP followed by an NBP capsule, a 14-day infusion of NBP followed by aspirin, or a 14-day infusion of ozagrel followed by aspirin.

After taking into account co and confounder, among the 535 subjects included in the efficacy analysis, 90-day treatment with NBP demonstrated a significant improvement than 14-day treatment with ozagrel as measured by the modified Rankin scale (mRS).

Where Ozagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.

According to Barthel index at day 90, there is no significant difference among the three groups. The rate of adverse events was similar among the three groups.

Furthermore, on a stroke induced by the middle cerebral artery occlusion (MCAO) in spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY), researchers compared the results of the pre-treatment of NBP administered to SHR and WKY daily for two months prior to MCAO and post-treatment of NBP given daily for seven consecutive days after MCAO.

In SHR, NBP pre- and post-treatment significantly lowered neurological deficit scores, reduced infarct volume, and minimized pathological changes in the penumbra area compared to oil-vehicle treated controls.

In other words, NBP pre- and post-treatment reduced the potential damage penumbra area through its neuroprotective activity.

However, in WKY, these beneficial effects were observed only in the post-treatment group, compared to SHR.

Dr. Zhang L, at the end of the experiment, wrote, "NBP could exert both preventive and therapeutic effects on ischemic stroke in SHR, but only exerted a therapeutic effect in WKY".


Taken altogether, Chinese celery processed high amounts of Dl-3-n-butylphthalide (NBP) may be considered a functional food for the post-treatment of patients with stroke.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial and Cui LY1, Zhu YC, Gao S, Wang JM, Peng B, Ni J, Zhou LX, He J, Ma XQ.(PubMed)
(2) DL-3-n-Butylphthalide, an anti-oxidant agent, prevents neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging and histological assessment by Zhang L1, Yu WH, Wang YX, Wang C, Zhao F, Qi W, Chan WM, Huang Y, Wai MS, Dong J, Yew DT.(PubMed)
(3) Stroke and Nutrition: A Review of Studies by Mehdi Foroughi,2 Mohsen Akhavanzanjani,2 Zahra Maghsoudi,2 Reza Ghiasvand,1,2Fariborz Khorvash,3 and Gholamreza Askari. (PMC)