Healthy Food Cucumber Normalizes the Blood Glucose in Diabetics

Blood glucose is the levels of sugar in the blood. Normally, high levels of sugar converted to energy or deposit as fat in the tissues through the production of insulin by the beta cells in the pancreas.

Hyperglycemia is a hallmark of diabetes caused by abnormally high levels of glucose in the blood due to improper diabetic management.

Diabetes is a medical condition characterized by insufficient insulin entering the bloodstream associated with clogged-up of insulin receptors or died off of beta cells in the pancreas.

Untreated high blood glucose over time has been found to induce diabetic complications with severe consequences.

According to the statistics provided by the WHO, The number of people with diabetes has risen from 108 million in 1980 to 422 million in 2014. The global prevalence of diabetes* among adults over 18 years of age has risen from 4.7% in 1980 to 8.5% in 2014.

In developing countries, diabetes prevalence has been rising more rapidly in middle- and low-income, compared to the diabetes prevalence in rich people in emerging countries. The results may be associated with economic prosperity over the past few decades as the rich in the emerging countries have replaced the traditional diet with the Western diet with high in saturated and trans fat accompanied with processed foods and red meat.

Some researchers suggested that by managing diet properly, you may reduce the risk of hyperglycemia.

* A low-carbohydrate diet
Unfortunately, according to the study by CSIRO Health Sciences and Nutrition, without active ongoing dietary advice, adherence to dietary intervention is poor(44).

* Probiotics
Probiotics could have beneficial effects beyond gastrointestinal health. They were found to improve certain metabolic disorders such as hypertension. Hypertension is caused by various factors and the predominant causes include an increase in cholesterol levels, incidence of diabetes, inconsistent modulation of renin and imbalanced sexual hormones(48).

* Adding small amount cinnamon into your daily diet
p-Methoxycinnamic acid (p-MCA), a cinnamic acid-enhanced glucose-, glibenclamide-induced insulin secretion(49)

* Adding garlic into your daily diet
Garlic improved glycemic control in addition to antihyperlipidemic activity. Garlic may be a good addition to the management of patients with diabetes and hyperlipidemia(51).

* Adding onion into your daily diet
Freeze-dried onion powder containing diet showed a significant decrease in blood phospholipids and triglycerides. Hepatic cholesterol, triglycerides, phospholipids which were elevated under diabetic condition were countered significantly by dietary onion(52).

* Adding green tea or coffee into your diet
Drinking green tea and coffee are associated with a reduced risk of diabetes. People who drink at 4 cups of tea per day may have a 16% lower risk of developing type 2 diabetes than non-tea drinkers, according to InterAct Consortium(53a). Coffee consumption decreased the risk of developing diabetes. The protective effect may exist aside from the influence of caffeine intake, according to the study by Gifu University Graduate School of Medicine(53b).

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

Researchers on finding a potential compound for the modulation of blood glucose investigated the effect of hydroalcoholic and ethanolic extract obtained from C. sativus seeds in a model of streptozotocin (STZ)-induced diabetic (type I) rats.

The selected normal and diabetic male Wistar rats (STZ, 60 mg/kg, intraperitoneal) were treated daily with vehicle (5 ml/kg), hydroalcoholic (0.2, 0.4, 0.8 g/kg) and buthanolic extract (0.2, 0.4, 0.8 g/kg) and glibenclamide (1 & 3 mg/kg) separately, for 9 days.

In the initial phase, C. sativus seeds extracts were not effective in reducing blood glucose levels (BGL) in both normal and diabetic rats.

However, after 9 days of treatment, both hydroalcoholic (22.5-33.8 %) and butanol (26.6- 45.0 %) extracts not only reduced levels of blood glucose but also inhibited the loss of body weight in diabetic rats compared to controls.

The results suggested a long-term intake of cucumber seeds modulates the blood glucose in diabetics without affecting the blood glucose in healthy individuals.

Based on the findings, researchers wrote, "C. sativus seeds extracts (hydroalcoholic and buthanolic) had a role in diabetes control probably through a mechanism similar to euglycemic agent".

Furthermore, in comparison with the effect of the fruit extract of C. metuliferus on normoglycemic and alloxan-induced hyperglycemic rats, researchers found the treatment at oral doses of 1000 and 1500 mg/kg showed an insignificant (P > 0.05) decrease in the blood glucose concentration of normoglycemic rats.

However, at the dose of 500 mg/kg, the fruit extract produced an insignificant (P > 0.05) decrease in blood glucose levels of alloxan-treated rats, compared to a significant (P < 0.05) decrease in the blood glucose concentration of hyperglycemic rats at 1000 and 1500 mg/kg oral dose points.

In other words, the cucumber fruits exerted the proportional efficacy in diabetics in a dose-dependent manner with no effect on blood glucose on nondiabetics.

Dr. Jimam N, the lead scientist, in the final report said, "the data suggested that the fruit extract did not alter the BGC level in normoglycemic rats, but had a potential hypoglycemic property in alloxan-induced hyperglycemic rats".

Taken altogether, cucumber may be used for the modulation of blood glucose concentration, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of Hydroalcoholic and Buthanolic Extract of Cucumis sativus Seeds on Blood Glucose Level of Normal and Streptozotocin-Induced Diabetic Rats by Minaiyan M1, Zolfaghari B, Kamal A.(PubMed)
(2) Evaluation of the Hypoglycemic Activity of Cucumis metuliferus (Cucurbitaceae) Fruit Pulp Extract in Normoglycemic and Alloxan-Induced Hyperglycemic Rats by Jimam N1, Wannang N, Omale S, Gotom B. (PubMed)
(3) Diabetes Prevention – The Diet by Kyle J. Norton