Endometriosis and Vitamins: The Effects of Vitamin B5

Posted by Chantel Martiromo, Research article by Kyle J. Norton

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

The Vitamins
Vitamin B5 is also known as pantothenic acid, played an important role in the forming of co-enzyme A and critical in the metabolism and synthesis of carbohydrates, proteins and fat. Vitamin B5 has a chemical structure formula of C9H17NO5.

Most women with endometriosis were found to have low levels of vitamin B5 during the menstrual cycle for what ever reason. Without enough vitamin B5 in a woman's body, it causes:
1. A weakened immune system
Since vitamin B5 is necessary in the metabolism of carbohydrates, it helps to generate energy for our body's cells. Without enough levels of vitamin B5, our body's immune system is weakened and is dangerous for the forming of free radicals and cell abnormalities(129)(130).

2. Poor circulation
Our liver is the first line of defense by secreting bile into the digestive system to produce good cholesterol, which helps to inhibit the bad cholesterol in the arteries(131). Without enough vitamin B5, bad cholesterol is left unchecked causing difficulty for blood circulation(132).

3. Increased risk of over-active uterine muscles
Liver helps in metabolism of fat. Without enough vitamin B5, it causes hormone imbalance(136) in the prostaglandins family leading to over-reaction of uterine muscles which in turn causes abdominal pain.

4. Increased tension of nervous system
Fat and protein are important for nourishing the cells in the nervous system. Low levels of vitamin B5 weakens the brain cell's function. This leads to symptoms of endometriosis such as anxiety, mood swings, and depression(128).

5. Increased risk of allergic reaction
Insufficient vitamin B5 in our body causes deficiency in co-enzyme A which is necessary for our body to react to sudden substances that enter our body, causing violently allergic reactions(135).

6. Acne
Fatty acid metabolism becomes less efficient and the individual is more prone to have acne(133)(134).

7. Hormonal imbalance
Besides helping to reduce acne, vitamin B5 also interacts with other members of the vitamin B complex by increasing the function of the adrenal glands which is necessary to balance hormones and promote normal growth of the body(5)(9).

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References
(128) Vitamin-regulated cytokines and growth factors in the CNS and elsewhere by Scalabrino G.(PubMed)
(129)Pantothenic acid in maintaining thiol and immune homeostasis by Moiseenok AG¹, Komar VI, Khomich TI, Kanunnikova NP, Slyshenkov VS.(PubMed)
(130) [Coenzyme A biosynthesis as universal mechanism of conjugation of exogenous and multiple pantothenic acid functions].[Article in Russian] by Moĭseenok AG, Gurinovich VA, Omel'ianchik SN, Slyshenkov VS.(PubMed)
(131) Hepatic CoA, S-acyl-CoA, biosynthetic precursors of the coenzyme and pantothenate-protein complexes in dietary pantothenic acid deficiency by Moiseenok AG, Sheibak VM, Gurinovich VA.(PubMed)
(132)Adrenal function in the pantothenic acid-deficient rat; liver glycogen, blood glucose, adrenal cholesterol and adrenal ascorbic acid levels.by HURLEY LS, MACKENZIE JB.(PubMed)
(133) A randomized, double-blind, placebo-controlled study of a novel pantothenic Acid-based dietary supplement in subjects with mild to moderate facial acne.by Yang M¹, Moclair B, Hatcher V, Kaminetsky J, Mekas M, Chapas A, Capodice J.(PubMed)
(134)Pantothenic acid deficiency as the pathogenesis of acne vulgaris by Leung LH.(PubMed)
(135) Role of the B vitamins in the immune response by Axelrod AE.(PubMed)
(136) Pantothenic acid in health and disease by Tahiliani AG¹, Beinlich CJ.(PubMed)