Posted by Chantel Martiromo, Research article by Kyle J. Norton
During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.
Women with endometriosis are found to have low levels of calcium 10 days before menstruation because of the unbalancing of levels of magnesium or inability of digestive absorption.
1. Immune system
Since calcium is vital for cell physiology, it helps to strengthen the communication of cells through waves of calcium(417) and other small molecules to cells hundreds of micrometers away, which is essential for the function of the immune system.
2. Cell growth(418)
Since calcium is vital for cell division, the right levels of calcium helps to maintain healthy cell growth and avoid cell abnormality(420) such as some peritoneal cells developing into endometrial cells in the abdomen.
3. Nervous system(419)
The strong bond between cells in the body through waves of calcium helps to strengthen the functions of cells in the nervous system(420) which decrease the risk of nervous tension resulting in symptoms of endometriosis. Deficiency of calcium weakens the communication process leading to confusion, memory loss, and depression(421).
4. Menstrual cramps(422)
Calcium is needed to maintain the uterine muscle's tone. Deficiency of calcium cause hyperactive muscles, including in the uterine muscles(423).
Since blood clotting requires the proteins made in the liver, calcium, vitamin K and platelets together with substances released from damaged tissue, deficiency of calcium causes heavy bleeding for women with endometriosis.
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(417) Electromagnetic field effects on cells of the immune system: the role ofcalcium signaling by Walleczek J.(PubMed)
(418) Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trialby Lappe JM1, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP.(PubMed)
(419) Vitamin A deficiency impairs postnatal cognitive function via inhibition of neuronal calcium excitability in hippocampusby Jiang W1, Yu Q, Gong M, Chen L, Wen EY, Bi Y, Zhang Y, Shi Y, Qu P, Liu YX, Wei XP, Chen J, Li TY.(PubMed)
(420) Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicityby Arundine M1, Tymianski M.(PubMed)
(421) Molecular mechanisms of calcium-dependent excitotoxicityby Sattler R1, Tymianski M.(PubMed)
(422)Calcium-permeable ion channels in pain signalingby Bourinet E, Altier C, Hildebrand ME, Trang T, Salter MW, Zamponi GW.(PubMed)
(423) Depletion of membrane cholesterol eliminates the Ca2+-activated component of outward potassium current and decreases membrane capacitance in rat uterine myocytesby Shmygol A1, Noble K, Wray S.(PubMed)
(424) Dietary intake of calcium, vitamins A and E and bleeding on probing in Sri Lankan preschoolersby Nanayakkara V, Ekanayake L, Silva R.(PubMed)
(425) Dental manifestation of primary idiopathic hypoparathyroidismby Srirangarajan S1, Satyanarayan A1, Ravindra S2, Thakur S3.(PubMed)