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Sunday, June 28, 2015

Endometriosis: The Effects of Minerals Magnesium


Posted by Chantel Martiromo, Research article by Kyle J. Norton

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.
Magnesium (Mg) is a trace mineral and has an atomic number of 32. Women with endometriosis were found to have low levels of magnesium during the menstrual cycle, causing symptoms of endometriosis and menstrual cramps. Please make sure to take magnesium together with vitamin C for better digestive absorption and the intake ratio of magnesium and calcium should always be 1 to 2

1. Abnormal cell development(408)
Deficiency of magnesium decreases the ability of DNA and RNA(409) synthesis in the body leading to cell abnormality, such as peritoneal cells growing into endometrial cells in the abdomen.

2. Protagslandins hormones
Magnesium is essential for liver to balance the protagslandins hormones that control the uterine muscles during the menstrual cycle. Deficiency of magnesium causes the over-production of certain hormones in the prostaglandins family resulting in menstrual cramps(410) for women with endometriosis.

3. Nervous system(408)
Deficiency of magnesium decreases the carbohydrate, protein and fat metabolism(411) of the liver leading to nutrient deficiency of nerve cells. Without enough nutrients for the nervous system it causes symptoms of endometriosis such as anxiety(412), and depression(413) as resulting of nervous system tensions.

4. Estrogen
Since magnesium helps in synthesis of protein and fat, it helps the liver to produce good estrogen which keeps the levels of bad estrogen in check resulting in lessening the levels of period pain and menstrual cramps(410).

5. Circulation system(409)
Magnesium also plays an important role in lowering the levels of bad cholesterol in the arteries(416) which helps to increase the blood circulation of oxygen and the carrying of nutrients to the body's brain cells. This helps to reduce tension of the nervous system and decreases the risk of heart diseases(414) and stroke(415).

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References
(408) Magnesium deficiency and alcohol intake: mechanisms, clinical significance and possible relation to cancer development (a review) by Rivlin RS.(PubMed)
(409) Magnesium in disease prevention and overall health by Volpe SL.(PubMed)
(410) Effectiveness of magnesium pidolate in the prophylactic treatment of primary dysmenorrhea by Benassi L1, Barletta FP, Baroncini L, Bertani D, Filippini F, Beski L, Nani A, Tesauri P, Tridenti G.(PubMed)
(411) Maternal magnesium deficiency in mice leads to maternal metabolicdysfunction and altered lipid metabolism with fetal growth restriction by Gupta M1, Solanki MH1, Chatterjee PK2, Xue X2, Roman A3, Desai N3, Rochelson B3, Metz CN4.(PubMed)
(412) Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment by Sartori SB1, Whittle N, Hetzenauer A, Singewald N.(PubMed)
(413) Depression and magnesium deficiency by Rasmussen HH1, Mortensen PB, Jensen IW.(PubMed)
(414) The role of magnesium deficiency in cardiovascular and intestinal inflammation by Weglicki WB1, Mak IuT, Chmielinska JJ, Tejero-Taldo MI, Komarov AM, Kramer JH.(PubMed)
(415)Magnesium deficiency exacerbates brain injury and stroke mortality induced by alcohol: a 31P-NMR in vivo study by Altura BM1, Gebrewold A, Zhang A, Altura BT, Gupta RK.(PubMed)
(416) Magnesium deficiency-related changes in lipid peroxidation and collagen metabolism in vivo in rat heart by Kumar BP1, Shivakumar K, Kartha CC.(PubMed)

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