Endometriosis: The Effects of Vitamin E

Posted by Chantel Martiromo, Research article by Kyle J. Norton


During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

                      The Vitamin E

Vitamin E, best known for its powerful antioxidant property is a fat soluble vitamin and can be stored in our body. We don't require to take it regularly.

1. Immune system(209)(210)
Since vitamin E is an antioxidant, it helps to increase liver function in fighting the forming of free radicals(212), abnormal cells and cancers(211). In endometriosis, it prevents the growth of abnormal endometrial cells to form implants and adhesion in other parts of the body excluding the endometrium.

2. Cell protection(213)(214)
Since vitamin E protects the fatty acid against degradation in the human body(210) that helps to prevent against the oxidation in cell membranes and cellular regions resulting in protecting against the breaking off of the capillary wall causing heavy blood flow(215) during menstruation.

3. Red blood cells(217)
Deficiency of vitamin E in women with endometriosis were also found to have anemia(218). It is caused by the faster than normal aging of red blood cells because of oxidative destruction of red blood cells(216).

4. Nervous system(219)
Since we already known that vitamin E is essential for increasing the ability of red blood cells to carry oxygen in the circulation system, it helps to nourish the brain cells fighting against symptoms of endometriosis such as mood swings, anxiety, and depression.

5. Hormone imbalance
Deficiency of vitamin E also interferes with normal functions of thyroid(220)(221) and pituitary(222) glands causing the decrease of levels of fatty acids resulting in endometrial menstrual cramps(223) which in turn result in the over-production of certain prostaglandins hormones.
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References
(209) Immunomodulatory effects of selenium and vitamin E on alterations in T lymphocyte subsets induced by T-2 toxin by Salimian J1, Arefpour MA, Riazipour M, Poursasan N.(PubMed)
(210) The ratio of dietary (n-6) to (n-3) fatty acids influences immune systemfunction, eicosanoid metabolism, lipid peroxidation and vitamin E status in aged dogs. Wander RC1, Hall JA, Gradin JL, Du SH, Jewell DE.(PubMed)
(211) Selenium and Vitamin E Cancer Prevention Trial: a nutrient approach to prostate cancer prevention by Dunn BK1, Ryan A, Ford LG.(PubMed)
(212) Oxygen free radicals and hypercholesterolemic atherosclerosis: effect ofvitamin E by Prasad K1, Kalra J.(PubMed)
(213) Vitamin E-enhanced IL-2 production in old mice: naive but not memory T cells show increased cell division cycling and IL-2-producing capacity by Adolfsson O1, Huber BT, Meydani SN.(PubMed)
(214) Vitamin E protection against chemical-induced cell injury. I. Maintenance of cellular protein thiols as a cytoprotective mechanism by Pascoe GA, Olafsdottir K, Reed DJ.(PubMed)
(215) Symptomatic vitamin E deficiency diagnosed after histological recognition of myometrial lipofuscinosis by Evans DJ1, Berney DM, Pollock DJ.(PubMed)
(216) Effect of linezolid on hematological and oxidative parameters in rats by Wang T, Guo D, Dong X, Mu L.(PubMed)
(217) Red cell metabolism in iron deficiency anemia. 3. The relationship between glutathione peroxidase, catalase, serum vitamin E, and susceptibility of iron-deficient red cells to oxidative hemolysis by Macdougall LG.(PubMed)
(218) Effects of erythropoietin and vitamin E-modified membrane on plasmaoxidative stress markers and anemia of hemodialyzed patients by Usberti M1, Gerardi G, Bufano G, Tira P, Micheli A, Albertini A, Floridi A, Di Lorenzo D, Galli F.(PubMed)
(219) Tocotrienol: the natural vitamin E to defend the nervous system? by Sen CK1, Khanna S, Roy S.(PubMed)
(220) Nitrite-induced alterations in sex steroids and thyroid hormones of Labeo rohita juveniles: effects of dietary vitamin E and L-tryptophan.by A1, Sahu NP, Pal AK, Akhtar MS.(PubMed)
(221) [Effect of vitamin E on general metabolism and on thyroid function in subjects with normal and altered basal metabolism].[Article in Undetermined Language] by JACONO G, D'ALESSANDRO B.(PubMed)
(222) Electron microscopic studies of anterior pituitary glands of vitamin E-deficient male mice by I Ichihara(PubMed)
(223) Menstrual pain in Danish women correlated with low n-3 polyunsaturatedfatty acid intake by Deutch B.(http://www.ncbi.nlm.nih.gov/pubmed/7588501PubMed)