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Tuesday, June 30, 2015

Endometriosis: The Effects of Minerals Potassium

Posted by Chantel Martiromo, Research article by Kyle J. Norton

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

Potassium(K) is a trace mineral with the chemical number 19. It occurs only as an ionic salt in nature and reacts violently with water. It is an important mineral for women with endometriosis because deficiency and incorrect ratio with sodium can interfere with the reproductive system's functions during the menstrual cycle.

1. Hormone imbalance
Potassium plays a vital role in regulating muscle tone including the uterine muscle, deficiency of potassium causes over-production of certain protagslandins members in the protagslandins family leading to over-active uterine muscles and severe endometrial menstrual cramps(427).
Deficiency of potassium may reduce the liver's function(428) of balancing the levels of fatty acids(429)(430) which are essential for building a normal muscle tone and regulate certain hormones during the menstrual cycle which causes menstrual pain(431)(432).

2. . Nervous system(426)
Deficiency of potassium reduces the process of passing nutrition through the cell including the cells in the nervous system leading to tension of nervous system(427) which causes a variety of symptoms of endometriosis such as memory loss, confusion, and anxiety(433).

3. Maintain fluid balancing(433)(434)
Distortion or depletion of levels of potassium reduces the ability to maintain fluid balance in the body causing water and salt retention, leading to a reduction in solute content in the renal papilla(434), and other symptoms, such as hypertension, vomiting, diarrhea, etc.

4. Circulatory system
Deficiency of potassium have found to enhance risk of the risk of hypertension and possibly stroke and combined with an inadequate thiamine intake has shown to produce heart disease in rats(428)

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(426) Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsyby Glasscock E1, Yoo JW, Chen TT, Klassen TL, Noebels JL.(PubMed)
(427) Lockless, S. W.; Zhou, M.; MacKinnon, R. (2007). "Structural and thermodynamic properties of selective ion binding in a K+ channel". PLoS Biol5 (5): e121. doi:10.1371/journal.pbio.0050121. PMC 1858713.PMID 17472437.
(428) Folis, R. H. (1942). "Myocardial Necrosis in Rats on a Potassium Low Diet Prevented by Thiamine Deficiency". Bull. Johns-Hopkins Hospital 71: 235.
(429)Low serum potassium level is associated with nonalcoholic fatty liverdisease and its related metabolic disorders by Sun K1, Lu J, Jiang Y, Xu M, Xu Y, Zhang J, Xu B, Sun J, Sun W, Ren C, Liu J, Wang W, Bi Y, Ning G.(PubMed)
(430) Fatty acid metabolism in adipose tissue, muscle and liver in health and disease by Frayn KN1, Arner P, Yki-Järvinen H.(PubMed)
(431) Menstrual pain in Danish women correlated with low n-3 polyunsaturatedfatty acid intakeby Deutch B.(PubMed)
(432) [Painful menstruation and low intake of n-3 fatty acids].[Article in Danish]by Deutch B.(PubMed)
(433) Brain Na(+), K(+)-ATPase Activity In Aging and Diseaseby de Lores Arnaiz GR1, Ordieres MG2.(PubMed)
(434) Intercalated cell BK-alpha/beta4 channels modulate sodium andpotassium handling during potassium adaptationby Holtzclaw JD1, Grimm PR, Sansom SC.(PubMed)

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