Endometriosis and Vitamins: The Effects of Vitamin B6

Posted by Chantel Martiromo, Research article by Kyle J. Norton

During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

The Vitamin B6 

Vitamin B6 is water soluble and a member of vitamin B complex, played an important role in amino acids metabolism for to maintaining the proper function in our body.
1. Hormone balancing
Vitamin B6 is essential for the production of the right levels of prostaglandins hormones in the prostaglandins family. Deficiency of vitamin B6 causes over active uterine muscles resulting in endometrial cramps(148).
2. Estrogen inhibitor
Vitamin B6 helps the live in protein and fat metabolism, thereby increasing the production of good estrogen that inhibits the bad estrogen produced by the body resulting in hormone re balancing and decrease the risk of cell abnormality and cancer(142)(143).
3. Anemia
Vitamin B6 increases the production of red blood cells that usually are depleted for the women with the heavy menstrual flow during menstruation(140)(141)(147).
4. Nervous system
Our nervous system requires variety of nutrients to function daily, vitamin B6 helps not only maintain a right levels of cholesterol but also increase the circulation of nutrients to our nervous system needed resulting in decreasing the symptoms of endometriosis, such as memory loss, confusion and anxiety(137)(138)(139).
5. Cell Growth
Vitamin B6 aids in the synthesis of DNA and RNA by maintaining the proper cell division and preventing cell abnormal growth such as peritoneal cells developing into endometrial cells(144)(145)(146).

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References
(137) Effect of vitamin B-6 nutrition on the levels of dopamine, dopamine metabolites, dopa decarboxylase activity, tyrosine, and GABA in the developing rat corpus striatum by Guilarte TR.(PubMed)
(138)Effects of perinatal vitamin B6 deficiency on dopaminergic neurochemistryby Guilarte TR, Wagner HN Jr, Frost JJ.(PubMed)
(139) Vitamin B6: deficiency diseases and methods of analysis.by Ahmad I¹, Mirza T, Qadeer K, Nazim U, Vaid FH.(PubMed)
(140)[Macrocytic anemia with anisocytosis due to alcohol abuse and vitamin B6 deficiency].[Article in Japanese] by Iwama H¹, Iwase O, Hayashi S, Nakano M, Toyama K.(PubMed)
(141)[Post-gastrectomized vitamin B12 deficient anemia with marked leukoerythroblastosis and ringed sideroblasts].[Article in Japanese] by Yoshimoto S¹, Takeuchi M, Tada A, Taguchi H, Manabe T.(PubMed)
(142)Taurine levels in blood and urine of vitamin B6-deficient and estrogen-treated rats by Lombardini JB.(PubMed)
(143)Metabolism of methionine in oral contraceptive users and control women receiving controlled intakes of vitamin B6.by Leklem JE, Linkswiler HM, Brown RR, Rose DP, Anand CR.(PubMed)
(144)Vitamin B6 suppresses growth and expression of albumin gene in a human hepatoma cell line HepG2 by Molina A¹, Oka T, Muńoz SM, Chikamori-Aoyama M, Kuwahata M, Natori Y.(PubMed)
(145) Vitamin B6 suppresses growth of the feline mammary tumor cell line FRM by Shimada D¹, Fukuda A, Kanouchi H, Matsumoto M, Oka T.(PubMed)
(146)Serum vitamin B6, folate, and homocysteine concentrations and oxidative DNA damage in Japanese men and women by Kuwahara K¹, Nanri A, Pham NM, Kurotani K, Kume A, Sato M, Kawai K, Kasai H, Mizoue T.(PubMed)
(147)Hyperhomocysteinemia in health and disease: where we are now, and where do we go from here ? by Lippi G, Plebani M.(PubMed)
(148) Premenstrual syndrome and beyond: lifestyle, nutrition, and personal facts by Bianco V¹, Cestari AM, Casati D, Cipriani S, Radici G, Valente I.(PubMed)