Posted by Chantel M. research contributed by PubMed
the study to determined whether early-life exposure to supplemental
folic acid (FA) - that may enhance DNA methylation of target genes - in
combination with ISO provides greater benefits to male bone development
than ISO alone. CD-1 dams were randomized to a low (0 mg/kg diet),
adequate (2 mg/kg diet) or supplemental (8 mg/kg diet) level of FA
during pregnancy and lactation. Offspring received corn oil or ISO (7
mg/kg of body weight per day) from postnatal day 1-10, posted in PubMed,
showed that early-life exposure to adequate FA+ISO provided functional
benefits to male bone development, while improvements induced by
supplemental FA+ISO were limited to a higher level of serum OPG.
Mechanistic studies are needed to better understand how FA and ISO
improve bone development in male offspring.
Chinese Secrets to Fatty Liver and Obesity Reversal
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