Influence of obesity on atherogenic dyslipidemia in women with polycystic ovary syndrome

  Posted by Chantel M. Research contributed by the US National Library of Medicine National Institutes of Health

The prevalence of childbearing age obesity is wide spreading in US, approximately, 50% of them are either overweight [body mass index (BMI) 25-29.9 kg/m(2)] or obese (BMI ≥ 30 kg/m(2)).
Influence of obesity on atherogenic dyslipidemia in women with polycystic ovary syndrome
In  a case-control study conducted in an academic medical centre of population consisted of 54 women of fertile age with PCOS and 60 controls adjusted for age and BMI, by the University Hospital Dr. Peset and University of Valencia, posted in PubMed, showed that Lean PCOS women exhibited lower HDL cholesterol and apolipoprotein AI levels than controls, although these differences were not associated with alterations of lipoprotein subfractions. All obese subjects, whether PCOS or controls, displayed lipid parameters typical of atherogenic dyslipidemia, although the former group had lower levels of large HDL, higher levels of small HDL subfractions and a higher percentage of VLDL than the latter. These differences were associated with a greater prevalence of non-A LDL pattern (25.0%) in obese PCOS subjects than in obese controls (4.3%).
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