The effects of soy milk and isoflavone supplements on cognitive performance in healthy, postmenopausal women

Posted by Chantel Martiromo. research contributed by the US National Library of Medicine National Institutes of Health

The decline in estrogen concentrations in women after menopause can contribute to health related changes including impairments in cognition, especially memory. In a study to investigate whether soy isoflavones (soy milk and supplement) could improve cognitive functioning in healthy, postmenopausal women of a total of 79 postmenopausal women, 48-65 years of age, completed a double-blind, placebo-controlled trial in which they were randomly assigned to one of three experimental groups: cow's milk and a placebo supplement (control); soy milk and placebo supplement (soy milk, 72 mg isoflavones/day); or cow's milk and isoflavone supplement (isoflavone supplement, 70 mg isoflavones/day), posted in PubMed, found that in contrast to predictions, soy isoflavones did not improve selective attention (Stroop task), visual long-term memory (pattern recognition), short-term visuospatial memory (Benton Visual Retention Test), or visuo-spatial working memory (color match task). Also, the soy milk group showed a decline in verbal working memory (Digit Ordering Task) compared to the soy supplement and control groups. Other study of the Effects of soy isoflavone supplementation on cognitive function in Chinese postmenopausal women, also idicated that 80-mg soy-derived isoflavone supplementation did not improve performance on standard neuropsychological tests and overall quality of life in generally healthy Chinese postmenopausal women, posted in PubMed.

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