Leucocytosis in women with polycystic ovary syndrome (PCOS) explained by obesity and insulin resistance.

Posted by Chantel M. Research contributed by the US National Library of Medicine National Institutes of Health

The prevalence of childbearing age obesity is wide spreading in US, approximately, 50% of them are either overweight [body mass index (BMI) 25-29.9 kg/m(2)] or obese (BMI ≥ 30 kg/m(2)).
Leucocytosis in women with polycystic ovary syndrome (PCOS) explained by obesity and insulin resistance.
Low-grade chronic inflammation predicts cardiovascular outcomes and is observed in women with polycystic ovary syndrome (PCOS). In the study of seventy pairs of women with and without PCOS, matched for age, body mass index (BMI) and IR (HOMA, QUICKI and Avignon index), generated from a larger cohort of 103 women with and 104 BMI-matched women without PCOS.to investigate whether this is entirely a cause or consequence of insulin resistance (IR), posted in PubMed, found that Low-grade inflammation occurs in PCOS. Increased hsCRP and cytokines are associated with IR, but increased WCC is observed even when IR is accounted for. The explanation for this and its clinical significance is unknown.

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