Posted by Chantel M. Research contributed by the US National Library of Medicine National Institutes of Health
The prevalence of childbearing age obesity is wide spreading in US,
approximately, 50% of them are either overweight [body mass index (BMI)
25-29.9 kg/m(2)] or obese (BMI ≥ 30 kg/m(2)).
Effect of obesity on polycystic ovary syndrome
While many women with polycystic ovary syndrome
(PCOS) are overweight, obese or centrally obese, the effect of excess
weight on the outcomes of PCOS is inconsistent,. According to the
University of Adelaide, Adelaide, posted in PubMed,
in searching for studies reporting outcomes according to body mass
index categories or body fat distribution, indicated that Overweight or
obese women with PCOS had decreased sex hormone-binding globulin (SHBG),
increased total testosterone, free androgen index, hirsutism, fasting
glucose, fasting insulin, homeostatic model assessment-insulin
resistance index and worsened lipid profile. Obesity
significantly worsened all metabolic and reproductive outcomes measured
except for hirsutism when compared to normal weight women with PCOS.
Overweight women had no differences in total testosterone, hirsutism,
total-cholesterol and low-density lipoprotein-cholesterol compared to
normal weight women and no differences in SHBG and total testosterone
compared to obese women. Central obesity was associated with higher fasting insulin levels. These results suggest that prevention and treatment of obesity is important for the management of PCOS.
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