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Wednesday, May 8, 2013

Early onset of obesity induces reproductive deficits

Posted by Chantel M. Research contributed by the US National Library of Medicine National Institutes of Health

The prevalence of childbearing age obesity is wide spreading in US, approximately, 50% of them are either overweight [body mass index (BMI) 25-29.9 kg/m(2)] or obese (BMI ≥ 30 kg/m(2)).
Early onset of obesity induces reproductive deficits 
The incidence of obesity is increasing rapidly all over the world and results in numerous health detriments, including disruptions in reproduction. According to the study by Universidade Estadual do Oeste do Paraná (UNIOESTE), posted in PubMed,  after weaning, female rats were treated with a cafeteria diet or a chow diet (control group) of which be able to induce obesity in female rats by increasing body and fat pad weight, which resulted in increased levels of triglycerides, total cholesterol, LDL and induced insulin resistance. The cafeteria diet also negatively affected female reproduction by reducing the number of oocytes and preantral follicles, as well as the thickness of the follicular layer. Obese females did not show preovulatory progesterone and LH surges, though plasma estradiol and prolactin showed preovulatory surges similar to control rats. Nevertheless, sexual receptiveness was not altered by cafeteria diet.

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