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Saturday, May 18, 2013

Procalcitonin (PCT) and Obesity polycystic ovary syndrome (PCOS)

Posted by Chantel M. Research contributed by the US National Library of Medicine National Institutes of Health

The prevalence of childbearing age obesity is wide spreading in US, approximately, 50% of them are either overweight [body mass index (BMI) 25-29.9 kg/m(2)] or obese (BMI ≥ 30 kg/m(2)).
Procalcitonin (PCT) and Obesity polycystic ovary syndrome (PCOS)
Procalcitonin (PCT) is a potential biomarker of obesity-related, low-grade inflammation in polycystic ovary syndrome (PCOS). In the study to  to investigate whether serum procalcitonin, high-sensitivity C-reactive protein (hs-CRP), white blood cell (WBC) and neutrophil counts are associated with polycystic ovary syndrome and with obesity, posted in PubNMed, found that  PCOS patients had significantly higher levels of serum PCT, hs-CRP, WBC, and neutrophil counts than healthy women. In control and PCOS groups, serum PCT, hs-CRP levels, WBC, and neutrophil counts were significantly increased in overweight and obese women compared with lean subjects. Serum PCT levels were positively correlated with BMI, waist/hip ratio, total cholesterol, serum triglycerides, LH/FSH, hs-CRP values, WBC and neutrophil counts in PCOS women. The increasing obesity was accompanied by a significant increase in the mean values of serum PCT and neutrophil counts in PCOS patients.

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