Posted by Chantel M. Research contributed by the US National Library of Medicine National Institutes of Health
The prevalence of childbearing age obesity is wide spreading in US,
approximately, 50% of them are either overweight [body mass index (BMI)
25-29.9 kg/m(2)] or obese (BMI ≥ 30 kg/m(2)).
Effect of obesity on toxicity in women treated with adjuvant chemotherapy for early-stage breast cancer
In the reviewed study to
provide more definite evidence regarding the role of dose modification
of chemotherapy in obese women with breast cancer
by systematically reviewing current literature regarding
chemotherapy-induced toxicity rates in obese and non-obese women with
early-stage breast cancer, posted in PubMed,
found that Seven studies found reduced toxicity in obese compared to
non-obese women. Of four studies, where dose capping was precluded or
statistically adjusted for, three found reduced toxicity in obese women.
These outcomes include less febrile neutropenia (body mass index (BMI)
>23.6; odds ratio (OR) 4.4; 95 % confidence interval (CI)
1.65-12.01), fewer hospital admissions (BMI >35; OR 0.61, 95 % CI
0.38-0.97), and fewer neutropenic events (BMI >25; OR 0.49; 95 % CI
0.37-0.66). Only a single study reported higher rates of toxicity in
obese women, but this study had significant methodological issues. As a
conclusion, we observed that obese patients tolerate chemotherapy better
than lean patients. However, this may be confounded by poorly specified
dose capping practices and the use of hematopoietic growth factors.
Chinese Secrets to Fatty Liver and Obesity Reversal
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