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Tuesday, July 30, 2019

Herbal Turmeric Reduces the Risk of Diabetic Nephropathy in Diabetes, According to Researchers

Diabetic nephropathy (diabetic kidney disease) is a complication of kidney damage caused by diabetes.

Long-term unmanaged hyperglycemia can damage the part of the kidneys thus reducing the kidney function in filter waste from the blood filters, leading to 'leaky' syndrome that allows protein into your urine.

Diabetic nephropathy is the 3 stage of kidney change in patients with diabetes. In this stage, patients may experience symptoms of abnormally elevated urinary albumin excretion, compared to the 15 and 300 μg/min in the baseline situation.


The progression of diabetic nephropathy that leads to an increased rate in albumin excretion is higher in patients with increased blood pressure.

More importantly, if high blood pressure is left untreated, diabetic nephropathy can induce persistent proteinuria >0.5 g/ 24 h that furtherly decline the renal function with the mean fall rate being around 1 ml/min/mo.

In other words, by treating hypertension and hyperglycemia in patients with diabetes, the progression of diabetics kidney disease may be slowed or preventable.

Some researchers suggested that
* By maintaining a healthy blood glucose levels and keeping them within the target range.

* By a change of healthful diet.

* By getting moderate and regular exercise

* By maintaining a healthy weight

* Particularly, by following a treatment plan, including the use of insulin or other medications.

Most common symptoms of diabetic nephropathy are worsening blood pressure control, protein in the urine, swelling of feet, ankles, hands or eyes, frequent urination, confusion or difficulty concentrating.

If you are diabetes associated with the aforementioned symptoms, please check with your doctor to rule out the possibility.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential and natural source for the treatment of diabetic complications, researchers examined the effects of bioactive compound curcumin anti-diabetic nephropathy (DN), the most common cause of end-stage renal disease in most parts of the world.

40 patients in the Diabetes Clinic of the Outpatient Department of Shiraz University of Medical Sciences on with overt type 2 diabetic nephropathy were randomized into a trial group (n = 20) and a control group (n = 20).

The treatment group received one capsule with each meal containing 500 mg turmeric, of which 22.1 mg was the active ingredient curcumin (three capsules daily) compared to the control group received three capsules identical in color and size containing starch for the period of 2 months.

Compared to the control group. patients treated with turmeric showed significantly reduced serum levels of transforming growth factor-β (TGF-β) and IL-8 associated with the production of pro-inflammatory cytokine and urinary protein excretion, the indications of kidney dysfunction.

The same results were also found in the comparison of the pre- and post-turmeric supplementation values.

Furthermore, there is no side effect reported in patients of the treatment group.


In other words, turmeric containing curcumin used in the experiment protects the kidney cells against the onset of diabetic nephropathy without inducing any adverse effects.

Dr. Khajehdehi P, the lead scientist based on the finding wrote, "Short-term turmeric supplementation can attenuate proteinuria, TGF-β, and IL-8 in patients with overt type 2 diabetic nephropathy and can be administered as safe adjuvant therapy for these patients".


Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of diabetic nephropathy, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of curcumin in experimental diabetic nephropathy by Prabhakar SS. (PubMed)
(2) Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study by Khajehdehi P1, Pakfetrat M, Javidnia K, Azad F, Malekmakan L, Nasab MH, Dehghanzadeh G. (PubMed)
(3) The Stages in Diabetic Renal Disease: With Emphasis on the Stage of Incipient Diabetic Nephropathy by C E Mogensen, C K Christensen and E Vittinghus(The Diabetes Association)

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