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Saturday, July 13, 2019

Phytochemical Alliin Inhibits the Onset of High Blood Pressure

High blood pressure, a condition characterized by elevated blood pressure in the arteries. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

In other words, the heart has to work harder to circulate blood to the body needs in high blood pressure patients. Long-term d elevate blood pressure raises the pressure of the heart, leading to damage to the heart tissue in facilitating the risk of cardiovascular disease.

According to the statistics provided by the CDC, approximately 54% of adults in the US are living with high blood pressure and half of that have an uncontrol condition.

Believe it or not, in the US, high blood pressure is a major cause of heart disease and stroke and a leading cause of death.

Many factors have been found to increase the risk of high blood pressure, including, tobacco or excessive alcohol drinking, chronic medical conditions such as kidney disease, diabetes and sleep apnea.

Some researchers suggested that the promotion of the Western diet with high consumption of salt may have a strong effect in increasing the prevalence of high blood pressure over the past few decades.

Dr. the lead scientist wrote, "Over the past century, salt has been the subject of intense scientific research related to blood pressure elevation and cardiovascular mortalities".


And, "The World Health Organization (WHO) strongly recommended reducing dietary salt intake as one of the top priority actions to tackle the global non-communicable disease crisis and has urged member nations to take action to reduce population-wide dietary salt intake to decrease the number of deaths from hypertension, cardiovascular disease, and stroke".

In other words, by following a healthy diet and moderate exercise, high blood pressure is preventable.


Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

On finding a natural compound for the treatment of hypertension, researchers examined the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin)on blood pressure.

The study included rats fed either by a 2% high cholesterol diet with and without aqueous garlic powder extract given orally to rats on a daily basis for 6 weeks or control rats fed a normal diet.

Compared to elevated levels of cholesterol in the rat fed with cholesterol diet without garlic extract, rats fed with a high cholesterol diet mixed with garlic powder showed a significant reduction in their serum cholesterol levels.

The high blood pressure of rats induced by cholesterol diet was also inhibited by garlic powder.

In other words, the blood pressure of the animals receiving garlic powder and high cholesterol diet was significantly lower as compared to other groups without affecting levels of glucose and protein.

Based on the results, researchers after taking other factors into account wrote, " garlic is beneficial in reducing...systolic blood pressure in hypercholesterolemic rats".

And, "Our experimental results show that garlic may beneficially affect two risk factors for... and hypertension".


Moreover, the Tel Aviv University study in the comparison of the effects of a new stable synthetic compound produced by a chemical reaction between allicin and the angiotensin-converting enzyme inhibitor captopril and alliin and captopril suggested CPSSA in high dose significantly decreased blood pressure, triglycerides, and homocysteine concentrations compared to alliin with a slight effect on SBP and Captopril (50mg/(kg day)) only improved blood pressure and homocysteine.

More precisely, Dr. Oron-Herman M, the lead scientist wrote, " the combined molecule CPSSA integrates the anti-hypertensive, lipid-lowering, and homocysteine-reducing effects of both allicin and captopril, making it a potential cardiovascular protective agent".

Taken altogether, alliin may be considered supplements for the prevention and treatment of hypertension, pending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M1, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T. (PubMed)
(2) The effects of S-allylmercaptocaptopril, the synthetic product of allicin and captopril, on cardiovascular risk factors associated with the metabolic syndrome by Oron-Herman M1, Rosenthal T, Mirelman D, Miron T, Rabinkov A, Wilchek M, Sela BA. (PubMed)
(3) Dietary Salt Intake and Hypertension by Sung Kyu Ha, M.D. (PMC)

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