Eggplant In Reduced Risk of Acute Inflammation and Treatment of Chronic Inflammatory Diseases

Eggplant may be used as a therapeutic and positive anti-inflammatory functional food without alternating the immune activity in the acute phase of infection, some scientists opinionated.

Eggplant with deep purple color is a species of S. melongena, belongs to the family Solanaceae cultivated in southern and eastern Asia since prehistory, and native to India.

Inflammation is a natural expression by the immune system in the induction of while blood cells for protection our body against infection caused by foreign invasion.

In the differentiation of water extract of Solanum melongena L. (Solanaceae) effect in induction of antioxidant, analgesic, hypolipidemic and antiallergic activity in mice induced by injection of trypsin or trans-cinnamoyl-LIGRLO-NH(2) (tc-NH(2)) into the hindpaw scientists found that oral administration of the extract at doses of 5, 10, and 100 mg/kg displayed a strong effect in inhibition of both paw edema and vascular permeability.

Further analysis also showed that the highest dose injection of 10 mg/kg expressed the greatest activity in compared to the others in significantly inhibited PAR2 agonist-induced myeloperoxidase (MPO) activity in stimulated immune function activated pro-inflammatory cytokines and tumor necrosis factor (TNF)-alpha expression to precipitate inflammation in response to the acute phase of infection.

After taking into account of other confounders, Dr. Umamageswari MS suggested that water extract of the S. melongena (SMWE) inhibits PAR2 agonist-induced mouse paw edema, through its anti inflammatory expression.


According to the investigated the inflammatory activities of aqueous extract of leaves of Solanum melongena Linn in carrageenan-induced paw oedema, in compared to standard medicine aspirin, oral application of Solanum melongena L. in different doses of 100mg/kg, 200mg/kg, 400mg/kg at 1(st) h, 3(rd) h, and 5(th) after injection revealed a significant effect in reduced inflammation linearly induced by carrageenan toxicity in a dose-dependent manner.

Additional differentiation, also suggested that the doses of 200mg/kg and 400 mg/kg of aqueous extract of S. melongena L showed the percentage of inhibition of 42.62% which is less than the standard drug aspirin which showed 64.5% inhibition.

In free radical perspective, the investigation of 4 our new lignanamides, melongenamides A-D (1-4), together with six known ones (5-10) isolated from the roots of Solanum melongena L. also demonstrated a significant activity in inhibitions of inflammatory effect caused by free radical species nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages through their antioxidant effect.

Interestingly, the study also found out that not all compounds extracted from the roots expressed the same levels of antioxidant properties in reduced inflammatory induced by ROS. In compared to other compounds, compound 1 exerted antioxidant effect without inhibited free radical nitric oxide production.


The findings suggested that eggplant may be used as a functional food in reduced risk of inflammation in acute infection and as an adjunct therapy in combination with the standard treatment of chronic inflammatory diseases.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) The aqueous extract of Solanum melongena inhibits PAR2 agonist-induced inflammation by Han SW1, Tae J, Kim JA, Kim DK, Seo GS, Yun KJ, Choi SC, Kim TH, Nah YH, Lee YM.(PubMed)
(2) Evaluation of anti-inflammatory activity of aqueous extract of leaves of solanum melongena linn. In experimental animals by Umamageswari MS1, Maniyar YA2.(PubMed)
(3) Anti-inflammatory lignanamides from the roots of Solanum melongena L by Sun J1, Gu YF1, Su XQ1, Li MM1, Huo HX1, Zhang J1, Zeng KW2, Zhang Q3, Zhao YF3, Li J4, Tu PF5.(PubMed)