Celery, the Potential Anti Liver Cancer Functional Food

Scientists in the cancer research team have found a functional vegetable that maybe the next pharmaceutical target to discover chemotherapy for the treatment of liver cancer.

Liver cancer is a medical and chronic condition characterized by cell growth disorderly and uncontrollably that starts in the surface of the inner lining of liver tissue as the result of alternation of DNA.

At the early stage of liver cancer, most patients do not experience any symptoms. However, as cancer continues to grow, in some stages, it will suppress the nearby nerve cell to facilitate local pain and discomfort.

At the advanced stage, the liver cancerous cell can travel a distance away to infect other healthy tissue and organs through the circulation of blood and fluids.

Researchers do not know why the liver cells of some people are susceptible to DNA alternation, while others do not, even they have the same health conditions, family history, and similar diet pattern.

Some researchers suggested that people who carry the infectious liver virus are associated with the major risk of liver cancer onset.

Researchers at the cancer program at the joint study led by the Technical University of Munich/Helmholtz Zentrum München in the confirmation of hepatitis B and C viruses risk of acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC) showed that the hepatitis B and C besides contributing to the development of liver cancer, they also cause over 1.3 million deaths per year worldwide.

According to the statistic, liver cancer is the second leading cause of cancer-related death worldwide, with HCC representing approximately 90% of all primary liver cancer cases.

Furthermore, patients who carry hepatitis B, and C are at the increased risk of liver cirrhosis, the early stage of liver cancer.

Moreover, in the reassessment of the relationship between the risk liver cancer in hepatitis B and C carrier patients, researchers found that the majority of viral-associated HCC patients developed liver cirrhosis before liver cancer onset, however, the hepatitis B virus infection can promote HCC development without the prior end-stage liver disease.

Therefore, if you are a carrier of hepatitis B and C, please make sure that you know how to protect yourself against the risk of liver cancer.

Some researchers suggested the best protection for people who have been recently exposed to the hepatitis B and C virus and are not vaccinated, are usually given the vaccine along with a shot of hepatitis B immune globulin (HBIG) and a combination of antiviral drugs, respectively.

Celery is a species of Apium graveolens, belonging to the family Apiaceae.

The vegetable is cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

Major phytochemicals found in celery include 3-n-butylphthalide, acetylenic, coumarins, phenolic acids, limonene, phthalides, and apigenin.

In the study to reaffirm the liver protective effect of celery seed, researchers launched an investigation to examine the anti-liver cancer activity of a methanolic extract of Apium graveolens seeds (celery seeds) on positive foci of gamma-GT in the liver of Wistar rats.


Application of celery seeds extracts demonstrated a liver protective effect in a dose-dependent against toxins induced hepatocarcinogenesis and gamma-GT positive foci in the rat treatment group.


5 days of pretreatment of celery seeds extracts stimulated the production of antioxidant enzymes in the host such as glutathione (GSH) and detoxifying enzymes such as quinone reductase (QR), glutathione-S-transferase (GST) and serum gamma-glutamyl transpeptidase (GGT) which were suppressed by the injection of toxins.

Dr. Sultana S, the lead author said, "A. graveolens is a potent plant against experimentally induced hepatocarcinogenesis in Wistar rats".


Furthermore, in the study of the liver-protective effects of perillyl alcohol, a monoterpene isolated from the essential oils of lavendin, peppermint, spearmint, cherries, celery seeds, and several other plants, the researchers found that
* Application of perillyl alcohol not only displays a significant activity against liver cancer but also inhibits the progression of pancreatic and mammary tumors.

* Perillyl alcohol actively induces apoptosis in liver tumor cells without affecting normal cells.

* Perillyl alcohol reverts tumor cells back to a differentiated state.

* Further differentiation indicated that Perillyl alcohol exerts the liver protective effect through activating the production of proteins responsible for programming cell death and deactivating the protein with function in pro cellular survival.

Taken altogether, celery may be considered a functional food for the prevention of liver cancer and an adjunct therapy combined with the primary medicine for the treatment of liver cancer, depending to the large human sample size and multi-center studies.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.




References
(1) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(2) Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism, and altered hepatic foci development by Sultana S1, Ahmed S, Jahangir T, Sharma S(PubMed)
(3) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
(4) Viral hepatitis and liver cancer by Marc Ringehan,1,2,3 Jane A. McKeating,4,5 and Ulrike Protzer. (PMC)