Bromelain Ameliorates Endometrial Pain

Endometriosis is a medical condition caused by the tissue of the endometrium that grows outside the uterus, leading to severe abnormal pain.

Most cases of endometriosis are found to involve the ovaries, fallopian tubes and the tissue lining the pelvis.

Some researchers suggested the cause of endometriosis is a result of a layer of endometriosis lining on the inside of the uterus is expelled, instead, some of the endometriosis tissues grow somewhere in the body in the last stage menstrual cycle (menstruation).


Endometriosis also reacts to hormone signals of the monthly menstrual cycle, by building up tissue, breaking it and eliminating, according to the stage of the menstrual period. Since they grow in somewhere other than in the uterus when they break, the period blood has no way to exit, causing blood attaching to the organs or lining of the abdomen, resulting in scars or adhesion as well as weakening the normal function of organs.

According to statistics, endometriosis affects
a) About 20% of reproductive-age women with endometriosis present but without symptoms.

b) About 55% of women who have developed the new onset of severe menstrual cramps.

c) About 25% of women with sub-fertility (less fertile than a normal couple)

Endometriosis can vary in appearance. It may be clear or white, reddish, brown or blue-black, and cysts. The condition can be classified according to the stage of severity:
* Minimal stage:
The top surface, few in number. Commonly they are found in the inside wall of uterus, ligaments, and ovary.

* Mild stage:
Deeper implants, greater numbers are presented. Commonly found in the same area as a minimal stage.

* Moderate stage:
Many implants, endometrial cysts present, affecting ovary function, causing scar tissues and adhesion is also present.

* Severe stage:
Intensive peritoneal implants, large endometromas present and dense adhesion.
Each woman experiences differently to endometriosis. Some women may have extensive endometrial tissues in their body but feel little or no pain, while other women may only be in the early stage of endometriosis but have excessive pain.



Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a potential ingredient for the treatment of endometriosis-associated pelvic pain, researchers evaluated the antioxidant activity of a preparation containing N-acetyl cysteine, alpha-lipoic acid, and bromelain.

The multicenter, open-label, non-comparative clinical trial included a sample of 398 patients with a mean age of 34.6 ± 7.2 years with endometriosis-associated pelvic pain.

According to the results of a combination of N-acetyl cysteine, alpha-lipoic acid and bromelain treatment after 6 months, in comparison of 92.7% of the patients with pain intensity > 4 on the visual analogue scale (VAS) at the baseline, the percentage was decreased to 87.2% (p = 0.074) at 3 months of treatment.

Also compared to the baseline, the percentage decreased even more at 82.7% (p < 0.05) at the 6 months treatment.

More importantly, the use of medicine for pain relief also was also reduced upon the application of the combination, according to the results of the experiment.

Dr. Lete I, the lead scientist said at the final report, "Women with endometriosis who wish to become pregnant and are treated with a preparation containing N-acetyl cysteine, alpha-lipoic acid and bromelain experienced a significant improvement in endometriosis-associated pelvic pain and required lower intake of rescue analgesics".

Taken altogether, bromelain used alone or combined with other remedies may be considered supplements for the prevention and treatment of endometrial pain, pending to the confirmation of the larger sample size and multicenter human study.


Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(2) Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study by Lete I1, Mendoza N2, de la Viuda E3, Carmona F. (PubMed)